The following railroads operate in the U.S. state of Mississippi.
| Name | Mark | System[1] | From | To | Successor | Notes |
|---|---|---|---|---|---|---|
| Alabama Central Railroad | SOU | 1871 | 1881 | East Tennessee, Virginia and Georgia Railroad | ||
| Alabama and Chattanooga Railroad | SOU | 1868 | 1877 | Alabama Great Southern Railroad | ||
| Alabama and Mississippi Railroad | A&M | 1902 | 1921 | Mississippi and Alabama Railroad, Mississippi Export Railroad | ||
| Alabama and Vicksburg Railway | A&V | IC | 1889 | 1959 | Illinois Central Railroad | |
| Arkansas City and Grenada Railroad | C&G | 1872 | 1873 | Greenville, Columbus and Birmingham Railroad | ||
| Avera and Northeastern Railroad | 1929 | 1933 | N/A | |||
| Batesville Southwestern Railroad | BSW | IC | 1910 | 1930 | N/A | |
| Bonhomie and Hattiesburg Southern Railroad | 1923 | 1972 | Illinois Central Gulf Railroad | |||
| Boyle and Sunflower River Railroad | IC | 1896 | 1900 | Yazoo and Mississippi Valley Railroad | ||
| Brookhaven and Pearl River Railway | IC | 1904 | 1911 | Mississippi Valley Company | ||
| Burlington Northern Inc. | BN | 1980 | 1981 | Burlington Northern Railroad | ||
| Burlington Northern Railroad | BN | 1981 | 1996 | Burlington Northern and Santa Fe Railway | ||
| Canton, Aberdeen and Nashville Railroad | IC | 1882 | 1953 | Illinois Central Railroad | ||
| Canton and Carthage Railroad | C&CA | 1927 | 1960 | N/A | ||
| Canton and Jackson Railroad | IC | 1841 | 1852 | New Orleans, Jackson and Great Northern Railroad | ||
| Canton, Kosciusko, Aberdeen and Tuscumbia Railroad | IC | 1852 | 1853 | New Orleans, Jackson and Great Northern Railroad | ||
| Central Mississippi Railroad | IC | 1877 | 1878 | Chicago, St. Louis and New Orleans Railroad | ||
| Chicago, St. Louis and New Orleans Railroad | IC | 1878 | 1951 | Illinois Central Railroad | ||
| Chickawsaha and Jackson Railroad | 1892 | 1914 | Chicora and Northwestern Railway | |||
| Chicora and Northwestern Railway | 1914 | 1931 | N/A | |||
| Clinton and Vicksburg Railroad | IC | 1831 | 1833 | Commercial and Railroad Bank of Vicksburg | ||
| Columbia, Lumberton and Gulf Railroad | IC | 1894 | 1900 | Gulf and Ship Island Railroad | ||
| Columbia and Silver Creek Railroad | CLSL | 1982 | 1988 | Gloster Southern Railroad | ||
| Columbus, Fayette and Decatur Railroad | C&G | 1881 | 1881 | Georgia Pacific Railway | ||
| Columbus and Greenville Railroad | C&G | C&G, SOU | 1920 | 1923 | Columbus and Greenville Railway | |
| Columbus and Greenville Railway | C&G | C&G | 1923 | 1972 | Illinois Central Gulf Railroad | |
| Commercial and Railroad Bank of Vicksburg | IC | 1833 | 1850 | Vicksburg and Jackson Railroad | ||
| Corinth and Counce Railroad | CCR | 1958 | 1991 | TennRail Corporation | ||
| Cybur, Gulf and Northwestern Railroad | 1914 | 1918 | ||||
| Pearl River Valley Railroad | PRV | 1917 | 2007 | N/A | ||
| DeKalb and Western Railroad | DK&W, DKW | 1916 | 1949 | N/A | ||
| Delta Southern Railway | C&G | 1904 | 1921 | Itta Bena and Belzoni Railroad | ||
| East Tennessee, Virginia and Georgia Railroad | SOU | 1881 | 1886 | East Tennessee, Virginia and Georgia Railway | ||
| East Tennessee, Virginia and Georgia Railway | SOU | 1886 | 1894 | Southern Railway | ||
| Ellisville and Laurel Railroad | GM&O | 1902 | 1902 | Mobile, Jackson and Kansas City Railroad | ||
| Fernwood, Columbia and Gulf Railroad | 1920 | 1972 | Illinois Central Gulf Railroad | |||
| Fernwood and Gulf Railroad | 1906 | 1920 | Fernwood, Columbia and Gulf Railroad | |||
| Gainesville and Mississippi Railroad | GM&O | 1852 | 1854 | Mississippi, Gainesville and Tuscaloosa Railroad | ||
| Georgia Pacific Railway | C&G, SOU | 1881 | 1894 | Southern Railway in Mississippi | ||
| Grand Gulf and Port Gibson Railroad | IC | 1852 | 1883 | New Orleans, Baton Rouge, Vicksburg and Memphis Railroad | ||
| Greenville, Columbus and Birmingham Railroad | C&G | 1873 | 1881 | Columbus, Fayette and Decatur Railroad | ||
| Greenville, Deer Creek and Rolling Fork Railroad | C&G | 1870 | 1880 | Greenville, Columbus and Birmingham Railroad | ||
| Gulf and Chicago Railroad | GM&O | 1889 | 1903 | Gulf and Chicago Railway | ||
| Gulf and Chicago Railway | GM&O | 1903 | 1909 | New Orleans, Mobile and Chicago Railroad | ||
| Gulf and Mississippi Railroad | GMSR | 1985 | 1988 | SouthRail Corporation | ||
| Gulf, Mobile and Northern Railroad | GM&N | GM&O | 1915 | 1940 | Gulf, Mobile and Ohio Railroad | |
| Gulf, Mobile and Ohio Railroad | GM&O | GM&O | 1938 | 1972 | Illinois Central Gulf Railroad | |
| Gulf and Ship Island Railroad | G&SI | IC | 1850 | 1945 | Illinois Central Railroad | |
| Helm and Northwestern Railroad | IC | 1904 | 1931 | N/A | ||
| Hiwannee and Tombigbee Railroad | 1906 | 1912 | N/A | |||
| Illinois Central Railroad | IC | IC | 1883 | 1972 | Illinois Central Gulf Railroad | |
| Illinois Central Gulf Railroad | ICG | 1972 | 1988 | Illinois Central Railroad | ||
| Itta Bena and Belzoni Railroad | 1923 | 1928 | N/A | |||
| Jackson and Brandon Railroad and Bridge Company | IC | 1841 | 1852 | Southern Railroad | ||
| Jackson and Brandon Railroad and Bridge Company | IC | 1836 | 1838 | Mississippi and Alabama Railroad | ||
| Jackson and Eastern Railway | GM&O | 1916 | 1929 | Gulf, Mobile and Northern Railroad | ||
| Kansas City, Memphis and Birmingham Railroad | SLSF | 1886 | 1928 | St. Louis – San Francisco Railway | ||
| Kentwood and Eastern Railroad | 1922 | N/A | ||||
| Kentwood and Eastern Railway | K&E | 1906 | 1922 | N/A | ||
| Kingston and Central Mississippi Railway | GM&O | 1901 | 1902 | Mobile, Jackson and Kansas City Railroad | ||
| Kosciusko and Southeastern Railroad | 1916 | 1931 | N/A | |||
| Leland Southwestern Railroad | IC | 1906 | 1916 | N/A | ||
| Liberty–White Railroad | 1902 | 1921 | N/A | |||
| Louisville and Nashville Railroad | L&N | L&N | 1880 | 1983 | Seaboard System Railroad | |
| Louisville, New Orleans and Texas Railway | IC | 1884 | 1892 | Yazoo and Mississippi Valley Railroad | ||
| Memphis, Birmingham and Atlantic Railroad | SLSF | 1885 | 1887 | Kansas City, Memphis and Birmingham Railroad | ||
| Memphis and Charleston Railroad | SOU | 1850 | 1898 | Memphis and Charleston Railway | ||
| Memphis and Charleston Railway | SOU | 1898 | 2002 | Norfolk Southern Railway | ||
| Memphis, Holly Springs and Mobile Railroad | SLSF | 1859 | 1867 | Memphis, Holly Springs, Okolona and Selma Railroad | ||
| Memphis, Holly Springs, Okolona and Selma Railroad | SLSF | 1867 | 1870 | Selma, Marion and Memphis Railroad | ||
| Memphis, Holly Springs and Selma Railroad | SLSF | 1881 | 1881 | Memphis, Selma and Brunswick Railroad | ||
| Memphis and New Orleans Railroad and Levee Company | IC | 1882 | 1887 | Louisville, New Orleans and Texas Railway | ||
| Memphis, Selma and Brunswick Railroad | SLSF | 1881 | 1885 | Memphis, Birmingham and Atlantic Railroad | ||
| Memphis and Vicksburg Railroad | IC | 1870 | 1884 | Louisville, New Orleans and Texas Railway | ||
| Meridian and Bigbee Railroad | MBRR, MB | 1952 | 1997 | M&B Railroad | ||
| Meridian and Bigbee River Railway | 1917 | 1952 | Meridian and Bigbee Railroad | |||
| Meridian, Brookhaven and Natchez Railroad | IC | 1891 | 1946 | Illinois Central Railroad | ||
| Meridian, Brookhaven and Natchez Railroad | IC | 1882 | 1888 | Illinois Central Railroad | ||
| Meridian and Deep Water Railway | 1911 | Meridian and Bigbee River Railway | ||||
| Meridian and Memphis Railway | M&M | GM&O | 1911 | 1929 | Gulf, Mobile and Northern Railroad | |
| Meridian Terminal Company | GM&O/ IC/ SOU | 1904 | 1958 | New Orleans and Northeastern Railroad | ||
| MidSouth Rail Corporation | MSRC | 1986 | 1993 | Kansas City Southern Railway | ||
| Minter City Southern and Western Railroad | IC | 1904 | 1932 | N/A | ||
| Mississippi and Alabama Railroad | 1922 | 1950 | N/A | |||
| Mississippi and Alabama Railroad | IC | 1905 | 1913 | Chicago, St. Louis and New Orleans Railroad | ||
| Mississippi and Alabama Railroad | IC | 1836 | 1841 | Jackson and Brandon Railroad and Bridge Company | ||
| Mississippi Central Railroad | MSC | IC | 1904 | 1967 | Illinois Central Railroad | |
| Mississippi Central Railroad | IC | 1852 | 1874 | New Orleans, St. Louis and Chicago Railroad | ||
| Mississippi Eastern Railway | ME | 1903 | 1942 | N/A | ||
| Mississippi, Gainesville and Tuscaloosa Railroad | GM&O | 1854 | 1870 | Mobile and Ohio Railroad | ||
| Mississippi and Schoona Valley Railroad | 1925 | 1926 | Mississippi and Skuna Valley Railroad | |||
| Mississippi Southern Railroad | 1922 | 1932 | N/A | |||
| Mississippi and Tennessee RailNet | MT | 1998 | 2003 | Mississippi Tennessee Railroad | ||
| Mississippi Tennessee Railroad | MTNR | 2003 | 2011 | Ripley and New Albany Railroad | ||
| Mississippi and Tennessee Railroad | IC | 1852 | 1889 | Chicago, St. Louis and New Orleans Railroad | ||
| Mississippi Valley Company | IC | 1872 | 1945 | Illinois Central Railroad | ||
| Mississippi Valley and Ship Island Railroad | IC | 1873 | 1883 | New Orleans, Baton Rouge, Vicksburg and Memphis Railroad | ||
| Mississippi and Western Railroad | 1917 | 1932 | N/A | |||
| Missouri Pacific Railroad | MP | MP | 1965 | 1982 | Illinois Central Gulf Railroad | |
| Mobile, Hattiesburg and Jackson Railroad | GM&O | 1888 | 1890 | Mobile, Jackson and Kansas City Railroad | ||
| Mobile, Jackson and Kansas City Railroad | GM&O | 1890 | 1909 | New Orleans, Mobile and Chicago Railroad | ||
| Mobile and Northwestern Railroad | IC | 1870 | 1889 | Louisville, New Orleans and Texas Railway, Mississippi Valley Company | ||
| Mobile and Ohio Railroad | GM&O | 1848 | 1940 | Gulf, Mobile and Ohio Railroad | ||
| Moss Point and Pascagoula Railroad | 1894 | 1903 | Pascagoula Street Railway and Power Company | |||
| Nashville and Mississippi Delta Railroad | SOU | 1890 | 1902 | Southern Railway | ||
| Natchez, Columbia and Mobile Railroad | 1892 | 1933 | N/A | |||
| Natchez and Eastern Railway | IC | 1906 | 1909 | Mississippi Central Railroad | ||
| Natchez and Jackson Railroad | IC | 1870 | 1872 | Natchez, Jackson and Columbus Railroad | ||
| Natchez, Jackson and Columbus Railroad | IC | 1872 | 1890 | Louisville, New Orleans and Texas Railway | ||
| Natchez and Southern Railway | MP | 1902 | 1965 | Missouri Pacific Railroad | ||
| Natchez Trace Railroad | NTR | 1982 | 1993 | Mississippi Central Railroad | ||
| New Orleans, Baton Rouge, Vicksburg and Memphis Railroad | IC | 1882 | 1884 | Louisville, New Orleans and Texas Railway | ||
| New Orleans Great Northern Railroad | NOGN | GM&O | 1905 | 1933 | New Orleans Great Northern Railway | |
| New Orleans Great Northern Railway | GM&O | 1933 | 1983 | Illinois Central Gulf Railroad | ||
| New Orleans, Jackson and Great Northern Railroad | IC | 1852 | 1874 | New Orleans, St. Louis and Chicago Railroad | ||
| New Orleans, Jackson and Northern Railroad | IC | 1877 | 1878 | Chicago, St. Louis and New Orleans Railroad | ||
| New Orleans, Mobile and Chattanooga Railroad | L&N | 1867 | 1871 | New Orleans, Mobile and Texas Railroad | ||
| New Orleans, Mobile and Chicago Railroad | GM&O | 1909 | 1915 | Gulf, Mobile and Northern Railroad | ||
| New Orleans, Mobile and Texas Railroad | L&N | 1871 | 1881 | Louisville and Nashville Railroad | ||
| New Orleans and Northeastern Railroad | N&NE | SOU | 1871 | 1969 | Alabama Great Southern Railroad | |
| New Orleans and Northwestern Railway | MP | 1884 | 1902 | Natchez and Southern Railway | ||
| New Orleans, St. Louis and Chicago Railroad | IC | 1874 | 1877 | Central Mississippi Railroad, New Orleans, Jackson and Northern Railroad | ||
| North East and South West Alabama Railroad | SOU | 1854 | 1868 | Alabama and Chattanooga Railroad | ||
| Oak Grove and Georgetown Railroad | 1904 | 1927 | N/A | |||
| Okolona, Houston & Calhoun City Railway | O.H.&C.C. | 1933 | 1939 | N/A | ||
| Pascagoula – Moss Point Northern Railroad | 1912 | 1915 | Alabama and Mississippi Railroad | |||
| Pascagoula Northern Railroad | 1909 | 1912 | Pascagoula – Moss Point Northern Railroad | |||
| Pearl and Leaf Rivers Railroad | IC | 1897 | 1904 | Mississippi Central Railroad | ||
| Richmond and Danville Railroad | C&G, SOU | 1889 | 1894 | Southern Railway | ||
| Ripley Railroad | GM&O | 1871 | 1872 | Ship Island, Ripley and Kentucky Railroad | ||
| Rosedale and Mississippi Central Railroad | IC | 1890 | 1898 | Yazoo and Mississippi Valley Railroad | ||
| St. Louis – San Francisco Railway | SLSF | SLSF | 1916 | 1980 | Burlington Northern Inc. | |
| St. Louis and San Francisco Railroad | SLSF | 1903 | 1916 | St. Louis – San Francisco Railway | ||
| Sanoody Valley Railroad | 1908 | 1915 | DeKalb and Western Railroad | |||
| Sardis and Delta Railroad | 1900 | 1929 | N/A | |||
| Seaboard System Railroad | SBD | 1983 | 1986 | CSX Transportation | ||
| Selma, Marion and Memphis Railroad | SLSF | 1870 | 1881 | Memphis, Holly Springs and Selma Railroad | ||
| Ship Island, Ripley and Kentucky Railroad | GM&O | 1872 | 1889 | Gulf and Chicago Railroad | ||
| Shubuta and Southwestern Railroad | 1905 | 1922 | N/A | |||
| Southern Railroad | IC | 1846 | 1867 | Vicksburg and Meridian Railroad | ||
| Southern Railway | SOU | SOU | 1894 | 1990 | Norfolk Southern Railway | |
| Southern Railway in Mississippi | C&G, SOU | 1894 | 1920 | Columbus and Greenville Railroad | ||
| SouthRail Corporation | SR | 1988 | 1993 | Kansas City Southern Railway | ||
| Sunflower and Eastern Railway | IC | 1901 | 1930 | N/A | ||
| Tallahatta Railroad | 1902 | 1919 | N/A | |||
| TennRail Corporation | 1991 | 1993 | Kansas City Southern Railway | |||
| Vicksburg and Jackson Railroad | IC | 1850 | 1857 | Southern Railroad | ||
| Vicksburg and Meridian Railroad | IC | 1867 | 1889 | Alabama and Vicksburg Railway | ||
| Vicksburg, Pensacola and Ship Island Railroad | IC | 1871 | 1873 | Mississippi Valley and Ship Island Railroad | ||
| West and East Railroad | IC | 1873 | 1886 | Yazoo and Mississippi Valley Railroad | ||
| West Feliciana Railroad | IC | 1831 | 1888 | Louisville, New Orleans and Texas Railway | ||
| Yazoo Delta Railway | IC | 1895 | 1900 | Yazoo and Mississippi Valley Railroad | ||
| Yazoo and Mississippi Valley Railroad | IC | 1882 | 1946 | Illinois Central Railroad |