The following is a list of Michigan State Historic Sites in Wexford County, Michigan. Sites marked with a dagger (†) are also listed on the National Register of Historic Places in Wexford County, Michigan.__TOC__
| width="30%" | Name | width="100px" | Image | Location | width="125px" | City | width="125px" | Listing date | |
|---|---|---|---|---|---|---|---|---|---|
| Battle of Manton Informational Designation | Rotary Park, US-131 south of Griswald Street | Manton | |||||||
| Caberfae Ski Resort Company Informational Site | Caberfae Road | Cadillac vicinity | |||||||
| Cadillac City Hall† | 201 North Mitchell Street | Cadillac | |||||||
| Cadillac Public Library† | 127 Beech Street | Cadillac | |||||||
| Clam Lake Canal | NE of 6093 M-115 | Cadillac | |||||||
| Cobbs and Mitchell Mill No. 1 Site Informational Site | 329 South Street at Lake Cadillac | Cadillac | |||||||
| Cobbs and Mitchell, Inc., Building | 100 East Chapin | Cadillac | |||||||
| Frank J. Cobbs House† | 407 East Chapin Street | Cadillac | |||||||
| First Wexford County Courthouse Informational Site | Northwest corner of State and Manistee streets | Sherman | |||||||
| Greenwood Disciples of Christ Church | 7303 N 35 Mile Road | Greenwood Township | |||||||
| Lumbering Industry | US-131, north of Manton | Manton vicinity | |||||||
| Manton Fire Barn and City Hall | Southeast corner of West Main and State Street | Manton | |||||||
| Charles T. Mitchell House† | 118 North Shelby Street | Cadillac | |||||||
| Shay Locomotive† | Cass Street, in the city park | Cadillac |