The following is a list of Michigan State Historic Sites in Sanilac County, Michigan. Sites marked with a dagger (†) are also listed on the National Register of Historic Places in Sanilac County, Michigan.__TOC__
| Name | Image | Location | width="125px" | City | width="125px" | Listing date | |||
|---|---|---|---|---|---|---|---|---|---|
| Brown City Banner Commemorative Designation | Main Street | Brown City | |||||||
| Brown City Community Schools | 4290 Second Street | Brown City | |||||||
| Buel Methodist Episcopal Church | Peck Road (M-90), 5 miles W of Croswell | Croswell | |||||||
| Old Catholic Rectory | 7229 Denissen Street | Lexington | |||||||
| Church of the Good Shepherd | 5646 Main Street, NW corner of Hubbard Street | Lexington | |||||||
| Croswell Chapel of Trinity Episcopal Church | 124 North Howard | Croswell | |||||||
| Thomas U. Dawson House | 6560 Ellsworth | Marlette | |||||||
| John L. Fead House† | 5349 Washington Street | Lexington | |||||||
| Flint and Pere Marquette Railroad Depot | 3325 Main Street | Marlette | |||||||
| Great Lake Storm of 1913 Informational Designation | Roadside Park on M-25, 1.5 miles south of Port Sanilac | Port Sanilac | |||||||
| Huckins-Norman Farmhouse | 7127 Lake Street | Lexington | |||||||
| Lexington Bank of B. R. Noble | 7245 Huron Avenue | Lexington | |||||||
| Lexington Town Hall and Masonic Temple | 5475–5477 Main Street | Lexington | |||||||
| Joseph M. Loop House† | 228 South Ridge Street | Port Sanilac | |||||||
| Marlette Township Library | 3116 Gurdon T. Wolfe Avenue | Marlette | |||||||
| Charles H. Moore Library† | 7239 Huron Avenue | Lexington | |||||||
| Thomas and Margaret Spencer Matthews Farm† | 5916 Gardner Line Road | Croswell | |||||||
| Charles H. Moore-Albert E. Sleeper House† | 7277 Simons Street | Lexington | |||||||
| New Carroll House | 4164 Main | Brown City | |||||||
| William Reuben Nims House† | 7156 Huron Avenue | Lexington | |||||||
| Rudolph Papst House | 734 Huron Avenue | Lexington | |||||||
| Port Sanilac Masonic and Town Hall† | 20 Ridge | Port Sanilac | |||||||
| Uri Raymond House | 111 S Ridge Street | Port Sanilac | |||||||
| Sanilac Petroglyphs Historic State Park† (20SL1) | 8251 Germania Road | Greenleaf Township | |||||||
| Snay Cemetery | Snay Road | Palms | |||||||
| The Wolfel House | Southeast corner of Main and Lester Streets | Lexington | |||||||
| Tug Sport Shipwreck Site† (20UH105) | 3 miles offshore in Lake Huron | Lexington | |||||||
| Judge Watson Beach House | 6993 Huron Avenue | Lexington | |||||||
| L. Philip Wixson House | 5774 Main Street | Lexington |