The following is a list of Michigan State Historic Sites in Monroe County, Michigan. Sites marked with a dagger (†) are also listed on the National Register of Historic Places in Monroe County, Michigan.__TOC__
| width="30%" | Name | width="100px" | Image | Location | width="125px" | Municipality | width="125px" | Listing date | |
|---|---|---|---|---|---|---|---|---|---|
| Alfred Wilkerson Grist Mill | 242 Toledo Street | Dundee | |||||||
| Bedford District No. 6 School | 25 East Sterns Road | Bedford Township | |||||||
| Bridge School | 96 Ida Maybee Road | Raisinville Township | |||||||
| Edward Loranger House † | 7211 South Stony Creek Road | Frenchtown Township | |||||||
| Exeter Township Hall | Southwest corner of Sumpter Road and Grant Street | Exeter Township | |||||||
| First Organized Public School District | T7S, R8 & 9E | Monroe vicinity | |||||||
| Fix House (Demolished, NRHP delisted 1981) | Sterling State Park 2800 State Park Road | Frenchtown Township | |||||||
| George Armstrong Custer Equestrian Monument † | Southwest corner of Elm Street and North Monroe Street | Monroe | |||||||
| Governor Robert McClelland House † | 47 East Elm Street | Monroe | |||||||
| Johnson-Phinney House | 22 West Second Street | Monroe | |||||||
| Lake Erie Informational Designation | Sterling State Park 2800 State Park Road | Frenchtown Township | |||||||
| Maybee Village Hall | 9051 Raisin Street | Maybee | |||||||
| Michigan Historic Crossroads Informational Site | Michigan Welcome Center Northbound Interstate 75 at 10 mile marker | Monroe Township | |||||||
| Michigan Southern Railroad | Intersection of First Street and Front Street | Monroe | |||||||
| Monroe County Informational Designation | 126 South Monroe Street | Monroe | |||||||
| Monroe Paper Industry | East Elm Street and North Dixie Highway | Monroe | |||||||
| Navarre–Anderson Trading Post † | 3775 North Custer Road | Frenchtown Township | |||||||
| Potter Cemetery / Public Act 525 of 2012 | 3700 East Sigler Road | Ash Township | 2017 | ||||||
| River Raisin Battlefield Site † | 333 North Dixie Highway | Monroe | |||||||
| Rudolph Nims House † | 206 West Noble Avenue | Monroe | |||||||
| St. John the Baptist Catholic Church | 511 Monroe Street | Monroe | |||||||
| St. John Evangelical Lutheran Church and Parsonage | 460 Riley Street | Dundee | |||||||
| St. Patrick Church | 2996 West Labo Road | Ash Township | |||||||
| Sawyer House † | 320 East Front Street | Monroe | |||||||
| Seitz Inn | 8941 North Custer Road | Raisinville Township | |||||||
| Toledo War Informational Designation | Michigan Welcome Center Northbound Interstate 75 at 10 mile marker | Monroe Township | |||||||
| Woodland Cemetery | 438 Jerome Street | Monroe |