The following is a list of Michigan State Historic Sites in Isabella County, Michigan. Sites marked with a dagger (†) are also listed on the National Register of Historic Places in Isabella County, Michigan.__TOC__
| width="30%" | Name | width="100px" | Image | Location | width="125px" | City | width="125px" | Listing date | |
|---|---|---|---|---|---|---|---|---|---|
| Central Michigan University Informational Designation | Adjacent to Warriner Hall, on campus | Mount Pleasant | |||||||
| Central Michigan University's First Class Informational Site | 201 South Main Street | Mount Pleasant | |||||||
| Doughty House† | 301 Chippewa St | Mount Pleasant | |||||||
| Isaac A. Fancher Building | 101 E Broadway | Mount Pleasant | |||||||
| Founding of Mount Pleasant Commemorative Designation | 200 Main Street, corner of Mosher | Mount Pleasant | |||||||
| Island Park Swimming Pool (demolished) | Lincoln Street at Main Street | Mount Pleasant | |||||||
| Mission Creek Cemetery | 1475 South Bamber Road, N of Pickard Rd., S of River Rd., on S side of Mission Creek | Mount Pleasant | |||||||
| Peter Richmond House | 109 West Locust | Mount Pleasant | |||||||
| Sacred Heart Academy | 316 East Michigan Avenue | Mount Pleasant | |||||||
| Saint John's Episcopal Church† | 206 West Maple Street | Mount Pleasant | |||||||
| Schoolhouse† | South Crawford Road, between Pickard and River Roads | Mount Pleasant | |||||||
| Shepherd Village Power House | 314 West Maple Street | Shepherd | |||||||
| Sherman City Union Church | Southeast corner of West Vernon and Wyman roads | Sherman City | |||||||
| Frank S. Sweeney House | 304 South Washington | Mount Pleasant |