The following is a list of Michigan State Historic Sites in Cass County, Michigan. Sites marked with a dagger (†) are also listed on the National Register of Historic Places in Cass County, Michigan.
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| width="30%" | Name | width="100px" | Image | Location | width="125px" | City | width="125px" | Listing date | |
|---|---|---|---|---|---|---|---|---|---|
| Cass County Courthouse | 110 North Broadway Street | Cassopolis | |||||||
| Cass County Office Building/Masonic Temple | 105 North Broadway Street | Cassopolis | |||||||
| Centennial Hall Building | 101-117 West Main Street | Marcellus | |||||||
| Chain Lake Baptist Church and Cemetery | 16853 Chain Lake Street | Calvin Township | |||||||
| District Schoolhouse | 17049 US-12 | Edwardsburg | |||||||
| First Methodist Episcopal Church | 31994 Middlecrossing Road | Silver Creek Township | |||||||
| First Universalist Church of Dowagiac | 306 Courtland Street | Dowagiac | |||||||
| Jarius Hitchcox House | 15197 US-12 | Union | |||||||
| Indian Lake Cemetery | School Street at Sink Road | Silver Creek Township | |||||||
| Carroll Sherman and Bessie E. Jones House† | 170 West Main Street | Marcellus | |||||||
| George Washington Jones House† | 180 West Main Street | Marcellus | |||||||
| Joseph Webster Lee House | 69302 Elkhart Road | Ontwa Township | |||||||
| Mason District No. 5 Schoolhouse† | 17049 US-12 | Mason Township | |||||||
| Methodist Episcopal Church† / The Old Rugged Cross | 61041 Vermont Street | Pokagon | |||||||
| George Newton House† | 20689 Marcellus Highway | Marcellus | |||||||
| Poe's Corners Informational Designation | Intersection of Patterson Hill Road and Born Street | Newberg Township | |||||||
| The Presbyterian Church | 68961 Lake Street | Edwardsburg | |||||||
| Sylvador T. Read House | 529 East State Street | Cassopolis | |||||||
| Sacred Heart of Mary Catholic Church | Southeast corner of Leach and Priest roads | Silver Creek Township | |||||||
| Smith's Chapel and Cemetery† | 29858 Redfield Road | Milton Township | |||||||
| Sumnerville Cemetery / Sumnerville Mounds | 33013 Pokagon Highway | Niles | |||||||
| Underground Railroad Informational Designation | Bonine Elk Park, M-60, 1/2 mile west of Vandalia | Vandalia | |||||||
| Wayne Township School District No. 7 School | 24020 Flanders St | Wayne Township |