IARC group 3 explained
IARC group 3 substances, chemical mixtures and exposure circumstances are those that can not be classified in regard to their carcinogenicity to humans by the International Agency for Research on Cancer (IARC). This category is used most commonly for agents, mixtures and exposure circumstances for which the level of evidence of carcinogenicity is inadequate in humans and inadequate or limited in experimental animals. Exceptionally, agents (mixtures) for which the evidence of carcinogenicity is inadequate in humans, but sufficient in experimental animals may be placed in this category when there is strong evidence that the mechanism of carcinogenicity in experimental animals does not operate in humans. Agents, mixtures and exposure circumstances that do not fall into any other group are also placed in this category.
The IARC Monographs on which this list is based assess the hazard linked to the agents, they do not assess the cancer risk of the agents.[1] The list is up-to-date as of January 2024.[2]
Agents and groups of agents
A
B
C
- Caffeine
- Cantharidin
- Caprolactam
- Captan
- Carbaryl
- 3-Carbethoxypsoralen
- Carmoisine
- Carrageenan
- Chloramine
- Chlordimeform
- Chlorinated drinking water
- Chloroacetonitrile
- Chlorobenzilate
- Chlorodibromomethane
- Chlorodifluoromethane
- Chloroethane
- Chlorofluoromethane
- 4-Chloro-meta-phenylenediamine
- Chloronitrobenzenes
- Chloropropham
- Chloroquine
- 5-Chloro-ortho-toluidine
- 2-Chloro-1,1,1-trifluoroethane
- Cholesterol
- Chromium(III) compounds
- Chromium, metallic
- Chrysoidine
- CI Acid Orange 3
- Cimetidine
- Cinnamyl anthranilate
- CI Pigment Red 3
- Citrinin
- Clofibrate
- Clomiphene citrate
- Coal dust
- Cobalt(II) sulfide
- Cobalt(II,III) oxide
- Other cobalt(II) compounds (not including soluble cobalt(II) salts, cobalt(II) oxide, cobalt(II,III) oxide, and cobalt(II) sulfde)
- Continuous glass filament
- Copper 8-hydroxyquinoline
- Coronene
- Coumarin
- m-Cresidine
- Cyclamates
- Cyclochlorotine
- Cyclohexanone
- 4H-Cyclopenta[''def'']chrysene
- 5,6-Cyclopenteno-1,2-benzanthracene
D
- D & C Red No. 9
- Dapsone
- Decabromodiphenyl oxide
- Deltamethrin
- Diacetylaminoazotoluene
- Diallate
- 1,2-Diamino-4-nitrobenzene
- 1,4-Diamino-2-nitrobenzene
- 2,5-Diaminotoluene
- Diazepam
- Diazomethane
- Dibenz[''a,c'']anthracene
- Dibenz[''a,j'']anthracene
- Dibenzo-p-dioxin
- Dibenzo[''a,e'']fluoranthene
- 13H-Dibenzo[''a,g'']fluorene
- Dibenzo[''h,rst'']pentaphene
- Dibenzo[''a,e'']pyrene
- Dibenzo[''e,l'']pyrene
- Dichloroacetonitrile
- Dichloroacetylene
- m-Dichlorobenzene
- o-Dichlorobenzene
- trans-1,4-Dichlorobutene
- 2,6-Dichloro-p-phenylenediamine
- Dicofol
- Didanosine
- Di(2-ethylhexyl) adipate
- Di(2-ethylhexyl) phthalate
- N,N'-Diethylthiourea
- 1,2-Dihydroaceanthrylene
- Dihydroxymethylfuratrizine
- Dimethoxane
- 3,3'-Dimethoxybenzidine-4,4'-diisocyanate
- p-Dimethylaminoazobenzenediazo sodium sulfonate
- 4,4'-Dimethylangelicin plus ultraviolet A radiation
- 4,5'-Dimethylangelicin plus ultraviolet A radiation
- N,N-Dimethylaniline
- 1,4-Dimethylphenanthrene
- 3,5-Dinitrotoluene
- Dinitrosopentamethylenetetramine
- 2,4'-Diphenyldiamine
- Disperse Yellow 3
- Disulfiram
- Dithranol
- Doxefazepam
- Doxylamine succinate
- Droloxifene
- Dulcin
E - G
H - L
M
N - O
P
Q - R
S
T
- Talc, not containing asbestiform fibres
- Tannic acid and tannins
- Temazepam
- 2,2',5,5'-Tetrachlorobenzidine
- Tetrakis(hydroxymethyl)phosphonium salts
- Theobromine
- Theophylline
- Thiourea
- Thiram
- Toluene
- Toremifene
- Toxins derived from Fusarium graminearum, F. culmorum and F. crookwellense (zearalenone, deoxynivalenol, nivalenol, and fusarenone X)
- Toxins derived from Fusarium sporotrichioides
- Trichlorfon
- Trichloroacetonitrile
- 1,1,2-Trichloroethane
- Triethanolamine
- Triethylene glycol diglycidyl ether
- Trifluralin
- 4,4',6-Trimethylangelicin plus ultraviolet A radiation
- 2,4,5-Trimethylaniline
- 2,4,6-Trimethylaniline
- 4,5',8-Trimethylpsoralen
- 2,4,6-Trinitrotoluene
- Triphenylene
- Tris(aziridinyl)-para-benzoquinone (Triaziquone)
- Tris(1-aziridinyl)phosphine oxide
- 2,4,6-Tris(1-aziridinyl)-s-triazine
- Tris(2-chloroethyl) phosphate
- 1,2,3-Tris(chloromethoxy)propane
- Tris(2-methyl-1-aziridinyl)phosphine oxide
U - Z
Mixtures
Exposure circumstances
- Calcium carbide production
- Flat-glass and specialty glass (manufacture of)
- Hair colouring products (personal use of)
- Leather goods manufacture
- Leather tanning and processing
- Lumber and sawmill industries (including logging)
- Paint manufacture (occupational exposure in)
- Pulp and paper manufacture
See also
External links
Notes and References
- Web site: IARC Monographs Preamble . January 2019 . International Agency for Research on Cancer . August 18, 2023. A cancer hazard is an agent that is capable of causing cancer, whereas a cancer risk is an estimate of the probability that cancer will occur given some level of exposure to a cancer hazard..
- Web site: List of Classifications . 2024-02-01 . IARC Monographs on the Identification of Carcinogenic Hazards to Humans .
