This is a list of number one singles on the Billboard Japan Hot 100 chart in Japan in 2010.
| Date | Song | Artist | ||
|---|---|---|---|---|
| January 4 | "Fuyu Koi" | Kanjani Eight | ||
| January 18 | "Fly Away" | Rake | ||
| January 25 | ||||
| February 1 | "Gloria" | Yui | ||
| February 8 | "Break Out!" | Tohoshinki | ||
| February 15 | "Modorenai Ashita" | Aiko | ||
| February 22 | "Love Yourself (Kimi ga Kirai na Kimi ga Suki)" | KAT-TUN | ||
| March 1 | "Sakura no Shiori" | AKB48 | ||
| March 8 | "Hitomi no Screen" | Hey! Say! JUMP | ||
| March 15 | "Troublemaker" | Arashi | ||
| March 22 | ||||
| March 29 | "Sakura" | Monkey Majik | ||
| April 5 | "Toki o Tomete" | Tohoshinki | ||
| April 12 | "Sakura Girl" | NEWS | ||
| April 19 | "Yūki 100%" | NYC | ||
| April 26 | "Happy" | Bump of Chicken | ||
| May 3 | "Mahō no Ryōri (Kimi Kara Kimi e)" | |||
| May 10 | "Go! Go | Maniac" | Ho-kago Tea Time | |
| May 17 | "Arigatō" | Ikimono-gakari | ||
| May 24 | "Going!" | KAT-TUN | ||
| May 31 | "Monster" | Arashi | ||
| June 7 | "Ponytail to Chouchou" | AKB48 | ||
| June 14 | "Rain" | Sid | ||
| June 21 | "Victory" | Exile | ||
| June 28 | ||||
| July 5 | "Okay" | Koshi Inaba | ||
| July 12 | "Wonderful World!!" | Kanjani Eight | ||
| July 19 | "To Be Free" | Arashi | ||
| July 26 | ||||
| August 2 | "This Is Love" | SMAP | ||
| August 9 | "One in a Million" | Tomohisa Yamashita | ||
| August 16 | "This Is Love" | SMAP | ||
| August 23 | "Hotaru" | Masaharu Fukuyama | ||
| August 30 | "Heavy Rotation" | AKB48 | ||
| September 6 | "Life (Me no Mae no Mukō e)" | Kanjani Eight | ||
| September 13 | "Wildflower" | Superfly | ||
| September 20 | "Love Rainbow" | Arashi | ||
| September 27 | "Motto Tsuyoku" | Exile | ||
| October 4 | ||||
| October 11 | "Kimi ni Todoke" | Flumpool | ||
| October 18 | "Dear Snow" | Arashi | ||
| October 25 | "Uchūhikōshi e no Tegami" | Bump of Chicken | ||
| November 1 | "Yoku Asobi Yoku Manabe" | NYC | ||
| November 8 | "Beginner" | AKB48 | ||
| November 15 | "Fighting Man" | NEWS | ||
| November 22 | "Hatenai Sora" | Arashi | ||
| November 29 | "Change Ur World" | KAT-TUN | ||
| December 6 | "Goodbye Happiness" | Hikaru Utada | ||
| December 13 | "Family (Hitotsu ni Naru Koto)" | KinKi Kids | ||
| December 20 | "Chance no Junban" | AKB48 | ||
| December 27 | "Arigatō (Sekai no Doko ni Ite mo)" | Hey! Say | JUMP |