This is a list of number one singles on the Billboard Brasil Hot 100 chart in 2010. Billboard publishes a monthly chart.
| Issue Date | Song | Artist(s) |
|---|---|---|
| January | "I Want to Know What Love Is" | Mariah Carey |
| February | ||
| March | ||
| April | ||
| May | ||
| June | "Tapa na Cara" | Zezé Di Camargo e Luciano |
| July | ||
| August | "Amo Noite e Dia" | Jorge & Mateus |
| September | ||
| October | "Tá Vendo Aquela Lua" | |
| November | "Adrenalina" | Luan Santana |
| December |