| Name | Class of | Notability |
|---|
| Michael L. J. Apuzzo | 1957 | Academic neurosurgeon, editor, futurist |
| Henry Baldwin | 1793 | U.S. Congressman, Associate Justice of the Supreme Court of the United States |
| Roger Sherman Baldwin | 1807 | U.S. Senator, Governor of Connecticut, defense attorney in Amistad case |
| Simeon E. Baldwin | 1857 | Chief Justice of the Connecticut Supreme Court, Governor of Connecticut |
| Wilson S. Bissell | 1865 | United States Postmaster General |
| Andy Bloch[5] | 1987 | Professional poker player |
| Edward Bouchet | 1870 | Physicist, first person of color to earn a Ph.D. from an American university |
| Augustus Brandegee | 1845 | U.S. House of Representatives |
| Chauncey Bunce Brewster | 1864 | Episcopal Bishop |
| - | Benjamin Brewster | 1878 | Episcopal Bishop of Maine |
| Nicholas Britell | 1999 | Composer, Pianist, and Film Producer |
| Guido Calabresi | 1949 | U.S. Court of Appeals judge, Dean of the Yale Law School |
| Walter Camp | 1876 | Founder of modern American football |
| Mei Chin | 1993 | Novelist and food critic |
| Elisha Cooper | 1989 | |
| John Davenport | n/a | Founder of New Haven, early advocate for the founding of a New Haven grammar school; regarded as Hopkins' founder |
| Thomas Frederick Davies, Sr. | 1849 | Third bishop of the Episcopal Diocese of Michigan |
| Nicholas Dawidoff | 1981 | Author |
| George DiCenzo | 1958 | Actor, Arts Activist |
| Asa Drury | n/a | Rector of Hopkins from 1829 to 1831 |
| Henry Durand | 1877 | Songwriter of Yale alma mater, "Bright College Years" |
| Timothy Dwight V | 1845 | President of Yale University |
| Henry W. Edwards | 1793 | U.S. Congressman, U.S. Senator, and Governor of Connecticut |
| Trey Ellis | 1980 | Novelist |
| William Eno | 1877 | Road safety advocate and inventor |
| Henry Farnam | 1870 | Railroad president |
| Orris Ferry | 1840 | U.S. Congressman, Senator |
| Ernest Flagg | 1876 | Architect |
| John Geanakoplos | 1971 | Economist |
| Josiah Willard Gibbs | 1854 | Father of Thermodynamics |
| Chauncey Goodrich | 1804 | Editor of the Webster's Dictionary |
| Arthur Hadley | 1872 | President of Yale University |
| John Hays Hammond | 1873 | Mining engineer, helped in founding of De Beers |
| Carolyn Hax | 1984 | Advice Columnist for the Washington Post |
| James Hillhouse | 1769 | U.S. Congressman, Senator |
| Edward Hopkins | n/a | Colonial Governor of Connecticut, Hopkins' first benefactor |
| William Hoppin | 1824 | Governor of Rhode Island |
| Edward House | 1877 | Diplomat, political adviser to Woodrow Wilson |
| William Henry Hunt | 1874 | Federal and state judge, territorial governor of Puerto Rico |
| William Morris Hunt | 1834 | Painter |
| Jared Ingersoll | 1762 | Delegate to the Continental Congress; signer of the United States Constitution for Pennsylvania; Federalist vice presidential candidate |
| Charles Ives | 1894 | Classical composer and insurance executive |
| Harold Hongju Koh | 1971 | Dean of the Yale Law School, Assistant Secretary of State for Democracy, Human Rights |
| Justin Kutcher | 1998 | Sports Commentator |
| Paul MacCready | 1943 | Aeronautical engineer |
| John Malone | 1959 | Telecommunications mogul |
| Joseph Mansfield | 1817 | American Civil War Major General |
| Jonathan Mostow | 1979 | Film director, writer, and producer |
| Henry Murphy | 1895 | Architect
- designed Nationalist Chinese monuments as well as Hopkins' 1925 campus, Baldwin Hall, and Hopkins House
|
| Francisco Palmieri | 1979 | Assistant Secretary of State for Western Hemisphere Affairs |
| Edwards Pierrepont | 1833 | New York Supreme Court justice; Minister Plenipotentiary to Great Britain; United States Attorney General |
| Abraham Pierson | 1664 | First rector of Yale's precursor, the Collegiate School |
| Benjamin Silliman | 1833 | Early professor of science |
| Alfred Terry | 1838 | American Civil War Major General, military commander of the Dakota Territory |
| Dan Wasserman | 1967 | Political cartoonist |
| Theodore Winthrop | 1841 | Author |
| Theodore Dwight Woolsey | 1816 | President of Yale University |
|
