The following is a list of persons from Spanish-speaking countries or of Hispanic descent who have travelled into space, sorted by date of first flight.
The first country listed is that of citizenship; the second, if any, is that of the Spanish-speaking country of birth or ancestry.
| Image | Name Birth date | Country | Comment | Missions (Launch date) | ||
|---|---|---|---|---|---|---|
| 1 | Arnaldo Tamayo Méndez January 29, 1942 | First person from Latin America to fly in space. First person of African descent in space. First Cuban in space. | Soyuz 38 (September 18, 1980) | |||
| 2 | Rodolfo Neri Vela February 19, 1952 | First Mexican in space. | STS-61-B (November 26, 1985) | |||
| 3 | Franklin Chang-Diaz April 5, 1950 | First Costa Rican astronaut | STS-61-C (January 12, 1986) STS-34 (October 18, 1989) STS-46 (July 31, 1992) STS-60 (February 3, 1994) STS-75 (February 22, 1996) STS-91 (June 2, 1998) STS-111 (June 5, 2002) | |||
| 4 | Sidney M. Gutierrez June 27, 1951 | First U.S.-born Hispanic astronaut | STS-40 (June 5, 1991) STS-59 (April 9, 1994) | |||
| 5 | Ellen Ochoa May 10, 1958 | First female Hispanic astronaut | STS-56 (April 8, 1993) STS-66 (November 3, 1994) STS-96 (May 27, 1999) STS-110 (April 8, 2002) | |||
| 6 | Michael Lopez-Alegria May 30, 1958 | -[1] | First Spanish-born astronaut | STS-73 (October 20, 1995) STS-92 (October 11, 2000) STS-113 (November 24, 2002) Soyuz TMA-9 (September 18, 2006) Axiom Mission 1 (April 8, 2022) | ||
| 7 | Carlos I. Noriega October 8, 1959 | First Peruvian-born astronaut | STS-84 (May 15, 1997) STS-97 (November 30, 2000) | |||
| 8 | Pedro Duque March 14, 1963 | First Spanish astronaut without dual citizenship | STS-95 (October 29, 1998) Soyuz TMA-3/2 (October 18, 2003) | |||
| 9 | John D. Olivas May 25, 1965 | STS-117 (June 8, 2007) STS-128 (August 28, 2009) | ||||
| 10 | George D. Zamka | STS-120 (October 23, 2007) STS-130 (February 8, 2010) | ||||
| 11 | Joseph M. Acaba May 17, 1967 | First Puerto Rican astronaut | STS-119 (March 15, 2009) Soyuz TMA-04M (May 15, 2012)[2] Soyuz MS-06 (September 12, 2017) | |||
| 12 | José M. Hernández August 7, 1962 | First migrant farm worker in space. | STS-128 (August 28, 2009) | |||
| 13 | Serena M. Auñón Apr. 9, 1976 | Soyuz MS-09 (June 6, 2018) | ||||
| 14 | Francisco RubioDecember 11, 1975 | (  El Salvador) | First salvadoreño astronaut. | Soyuz MS-22 (Sept. 21, 2022) |
| Image | Name Birth date | Country | Comment |
|---|---|---|---|
| José López Falcón February 8, 1950 | Backup for Arnaldo Tamayo Mendez on Soyuz 38 | ||
| Ricardo Peralta y Fabi | Backup for Rodolfo Neri Vela on STS-61-B | ||
| Fernando Caldeiro June 12, 1958 | Died October 3, 2009. | ||
| Marcos Berríos 1984 | Selected as part of NASA Astronaut Group 23 | ||