| Post: | First Lady |
| Body: | Maryland |
| Insignia: | Seal of Maryland (reverse).svg |
| Insigniacaption: | Seal of the State of Maryland |
| Insigniasize: | 150px |
| Incumbent: | Dawn Moore |
| Incumbentsince: | January 18, 2023 |
| Residence: | Government House |
| Inaugural: | Ann Jennings Johnson |
| Website: | Official website |
The spouse of the governor of Maryland is given an honorary position, styled as First Lady or First Gentleman of the State of Maryland. To date there have been no female governors of the State of Maryland, and all first spouses have been first ladies.
| Name | Took office | Left office | Spouse of | |
|---|---|---|---|---|
| Ann Jennings Johnson | 1777 | 1779 | Thomas Johnson | |
| Mary Digges Lee | 1779 | 1782 | Thomas Sim Lee | |
| Anna Maria Tilghman Chew (hostess for widower) | 1782 | 1785 | William Paca | |
| none (Smallwood never married) | 1785 | 1788 | William Smallwood | |
| Peggy Chew Howard | 1788 | 1791 | John Eager Howard | |
| none (Plater was a widower) | 1791 | 1792 | George Plater | |
| Juliana Jennings Brice (acting) | 1792 | 1792 | James Brice (acting) | |
| Mary Digges Lee | 1792 | 1794 | Thomas Sim Lee | |
| widower | 1794 | 1797 | John Hoskins Stone | |
| widower | 1797 | 1798 | John Henry | |
| Henrietta Margaret Hill Ogle | 1798 | 1801 | Benjamin Ogle | |
| Sophia Sprigg Mercer | 1801 | 1803 | John Francis Mercer | |
| Priscilla Mackall Bowie[1] | 1803 | 1806 | Robert Bowie | |
| Elizabeth Harriot Robertson Wright | 1806 | 1809 | Robert Wright | |
| Sally Scott Murray Lloyd | 1809 | 1811 | Edward Lloyd | |
| Priscilla Mackall Bowie | 1811 | 1812 | Robert Bowie | |
| Mary Stoughton Sloss Winder | 1812 | 1816 | Levin Winder | |
| Priscilla Dorsey Ridgely | 1816 | 1819 | Charles Carnan Ridgely | |
| Sarah Goldsborough | 1819 | 1819 | Charles Goldsborough | |
| Violetta Lansdale Sprigg | 1819 | 1822 | Samuel Sprigg | |
| Eliza May Stevens | 1822 | 1826 | Samuel Stevens, Jr. | |
| Eleanor Lee Wallace Kent | 1826 | 1826 | Joseph Kent | |
| none (Kent was a widower) | 1826 | 1828 | ||
| Alice Contee Kent | 1828 | 1829 | ||
| Mary Clare Maccubbin Martin | 1829 | 1830 | Daniel Martin | |
| Julianna Stevenson Carroll | 1830 | 1831 | Thomas King Carroll | |
| Mary Clare Maccubbin Martin | 1831 | 1831 | Daniel Martin | |
| Prudence Gough Ridgely Howard | 1831 | 1833 | George Howard | |
| Elizabeth Courts Thomas | 1833 | 1836 | James Thomas | |
| Mary Wallace Veazey | 1836 | 1839 | Thomas Veazey | |
| Susan Orrick Sulivane Grason | 1839 | 1842 | William Grason | |
| Sally Campbell Preston McDowell Thomas Miller | 1842 | 1842 | Francis Thomas | |
| none (couple separated) | 1842 | 1845 | ||
| Adeline Mackubin Kent Pratt | 1845 | 1848 | Thomas Pratt | |
| Sarah Maria Kerr Thomas | 1848 | 1851 | Philip Francis Thomas | |
| Esther Winder Polk Lowe | 1851 | 1854 | Enoch Louis Lowe | |
| Mary Tolly Dorsey Ligon | 1854 | 1858 | Thomas Watkins Ligon | |
| none (Hicks was a widower) | 1858 | 1862 | Thomas Holliday Hicks | |
| Elizabeth Kell Bradford | 1862 | 1866 | Augustus Bradford | |
| Elizabeth Sherlock Swann | 1866 | 1869 | Thomas Swann | |
| Alice Carter Bowie | 1869 | 1872 | Oden Bowie | |
| Louisa Hollingsworth Whyte | 1872 | 1874 | William Pinkney Whyte | |
| none (Groome not married) | 1874 | 1876 | James Black Groome | |
| none (Carroll was a widower) | 1876 | 1877 | John Lee Carroll | |
| Mary Carter Thompson Carroll | 1877 | 1880 | ||
| Clara Jenness Hamilton | 1880 | 1884 | William Thomas Hamilton | |
| Georgine Urquhart McLane | 1884 | 1885 | Robert Milligan McLane | |
| Mary Elizabeth Staplefort Lloyd | 1885 | 1888 | Henry Lloyd | |
| Nannie Rider Jackson | 1888 | 1892 | Elihu Emory Jackson | |
| Mary Ridgely Preston Brown | 1892 | 1895 | Frank Brown | |
| Mary Ridgely Brown Lee (hostess for widower) | 1895 | 1896 | ||
| Elizabeth Tasker Lowndes | 1896 | 1900 | Lloyd Lowndes, Jr. | |
| Mary Frances Richardson Smith | 1900 | 1904 | John Walter Smith | |
| Emma Nicodemus Warfield | 1904 | 1908 | Edwin Warfield | |
| Lynn Shaffer Ewing (hostess; Crothers never married) | 1908 | 1912 | Austin Lane Crothers | |
| Ellen Showell Goldsborough | 1912 | 1916 | Phillips Lee Goldsborough | |
| Gertrude Johnson Harrington | 1916 | 1920 | Emerson Harrington | |
| Elizabeth Caskie Cabell Ritchie (hostess) | 1920 | 1931 | Albert Ritchie | |
| none | 1931 | 1935 | ||
| Edna Viola Amos Nice | 1935 | 1939 | Harry Nice | |
| Eugenia Byrnes O'Conor | 1939 | 1947 | Herbert O'Conor | |
| Dorothy Byron Lane | 1947 | 1951 | William Preston Lane, Jr. | |
| Honolulu Claire Manzer McKeldin | 1951 | 1959 | Theodore McKeldin | |
| Helen Avalynne Gibson Tawes | 1959 | 1967 | J. Millard Tawes | |
| Elinor Judefind Agnew | 1967 | 1969 | Spiro Agnew | |
| Barbara Oberfeld Mandel | 1969 | 1974 | Marvin Mandel | |
| Jeanne Blackistone Dorsey Mandel | 1974 | 1979 | ||
| Mathilde Boal Lee (acting) | 1977 | 1979 | Blair Lee III (acting) | |
| Jeanne Blackistone Dorsey Mandel | 1979 | 1979 | Marvin Mandel | |
| Patricia Donoho Hughes | 1979 | 1987 | Harry Hughes | |
| Hilda Mae Snoops (hostess; Schaefer never married) | 1987 | 1995 | William Donald Schaefer | |
| Frances Hughes Glendening | 1995 | 2001 | Parris Glendening | |
| none (Glendening not married) | 2001 | 2002 | ||
| Jennifer Crawford | 2002 | 2003 | ||
| Kendel Sibiski Ehrlich | 2003 | 2007 | Bob Ehrlich | |
| Catherine Curran O'Malley | 2007 | 2015 | Martin O'Malley | |
| Yumi Hogan | 2015 | 2023 | Larry Hogan | |
| 2023 | serving | Wes Moore |