A great number of airlines and air forces from several countries included the Douglas DC-6 in their fleets at some point in time. Today most DC-6s are inactive, stored, or preserved in museums; although a number are still flying in northern bush operations in Alaska and Canada, while several are based in Europe and a few other DC-6s are still in operation for small carriers in South America.
Below are listed known operators of this airplane, both past and present (♠ indicate Original operators).