The table below lists the largest municipalities (Municipios) in Colombia by population, using data from the most recent population estimates of Colombia in 2020.[1]
| Rank | Municipality | Department | Population in 2020 | |
|---|---|---|---|---|
| scope=row style="text-align:center;" | 1 | Bogotá | capital district | 7,732,161 |
| scope=row style="text-align:center;" | 2 | Medellín | Antioquia | 2,519,592 |
| scope=row style="text-align:center;" | 3 | Cali | Valle del Cauca | 2,264,427 |
| scope=row style="text-align:center;" | 4 | Barranquilla | Atlántico | 1,275,264 |
| scope=row style="text-align:center;" | 5 | Cartagena | Bolívar | 1,017,616 |
| scope=row style="text-align:center;" | 6 | Cúcuta | Norte de Santander | 770,173 |
| 7 | Soacha | Cundinamarca | 715,252 | |
| 8 | Soledad | Atlántico | 646,678 | |
| 9 | Bucaramanga | Santander | 600,098 | |
| 10 | Ibagué | Tolima | 536,439 | |
| 11 | Bello | Antioquia | 544,549 | |
| 12 | Villavicencio | Meta | 553,409 | |
| 13 | Santa Marta | Magdalena | 530,107 | |
| 14 | Valledupar | Cesar | 526,238 | |
| 15 | Montería | Córdoba | 507,463 | |
| 16 | Pereira | Risaralda | 477,068 | |
| 17 | Manizales | Caldas | 445,669 | |
| 18 | Pasto | Nariño | 402,073 | |
| 19 | Neiva | Huila | 367,781 | |
| 20 | Palmira | Valle del Cauca | 355,712 | |
| 21 | Popayán | Cauca | 328,217 | |
| 22 | Buenaventura | Valle del Cauca | 317,881 | |
| 23 | Floridablanca | Santander | 317,541 | |
| 24 | Armenia | Quindío | 302,613 | |
| scope=row style="text-align:center;" | 25 | Sincelejo | Sucre | 295,047 |
| scope=row style="text-align:center;" | 26 | Itagüí | Antioquia | 287,981 |
| scope=row style="text-align:center;" | 27 | Nariño | 260,054 | |
| 28 | Envigado | Antioquia | 238,656 | |
| 29 | Tuluá | Valle del Cauca | 224,706 | |
| 30 | Dosquebradas | Risaralda | 222,717 |