The Central Missouri Mules football team representing the University of Central Missouri (UCM), has had 12 players selected in the National Football League (NFL) since the league began holding drafts in 1936). This includes one player selected in the fifth round. The Green Bay Packers lead all teams and have drafted two Mules.
Each NFL franchise seeks to add new players through the annual NFL Draft. The draft rules were last updated in 2009. The team with the worst record from the previous year picks first, the next-worst team second, and so on. Teams that did not make the playoffs are ordered by their regular-season record with any remaining ties broken by strength of schedule. Playoff participants are sequenced after non-playoff teams, based on their round of elimination (wild card, division, conference, and Super Bowl).
| B | Back | K | Kicker | NT | Nose tackle |
| C | Center | LB | Linebacker | BB | Blocking back |
| DB | Defensive back | P | Punter | HB | Halfback |
| DE | Defensive end | QB | Quarterback | WR | Wide receiver |
| DT | Defensive tackle | RB | Running back | G | Guard |
| E | End | OT | Offensive tackle | TE | Tight end |
| FB | Fullback | ||||
| Selected to a Pro Bowl | |||||
| † | Won an NFL championship | ||||
| ‡ | Selected to a Pro Bowl and won an NFL championship | ||||
See also: National Football League Draft.
| 1967 | 13 | 340 | WR | Green Bay Packers | — | ||
| 1968 | 13 | 138 | T | Washington Redskins | — | ||
| 1969 | 17 | 428 | T | Green Bay Packers | — | ||
| 1970 | 13 | 333 | RB | Cleveland Browns | — | ||
| 1971 | 15 | 385 | WR | Detroit Lions | — | ||
| 1974 | 14 | 349 | DB | Los Angeles Rams | — | ||
| 1978 | 11 | 302 | WR | Baltimore Colts | — | ||
| 1987 | 8 | 213 | DT | Buffalo Bills | — | ||
| 2001 | 7 | 207 | DE | Dallas Cowboys | — | ||
| 2004 | 5 | 153 | LB | Baltimore Ravens | — | ||
| 2006 | 6 | 176 | TE | San Francisco 49ers | — | ||
| 2021 | 5 | 168 | TE | Minnesota Vikings | — |