These are the singles that reached number one on the Top 100 Singles chart in 1990 as published by Cash Box magazine.
| Indicates best-performing single of 1990 |
| Issue date | Song | Artist | |
|---|---|---|---|
| January 6 | "Another Day in Paradise" | Phil Collins | |
| January 13 | |||
| January 20 | "Pump Up the Jam" | Technotronic featuring Felly | |
| January 27 | |||
| February 3 | "Downtown Train" | Rod Stewart | |
| February 10 | "Opposites Attract" | Paula Abdul with Wild Pair | |
| February 17 | |||
| February 24 | "Two to Make It Right" | ||
| March 3 | "Dangerous" | ||
| March 10 | "Escapade" | Janet Jackson | |
| March 17 | |||
| March 24 | |||
| March 31 | "Black Velvet" | ||
| April 7 | |||
| April 14 | "Love Will Lead You Back" | ||
| April 21 | "I'll Be Your Everything" | Tommy Page | |
| April 28 | "Nothing Compares 2 U" | Sinéad O'Connor | |
| May 5 | |||
| May 12 | |||
| May 19 | bgcolor=#FFFF99 rowspan="2" | "Vogue" | Madonna |
| May 26 | |||
| June 2 | "All I Wanna Do Is Make Love To You" | Heart | |
| June 9 | "Vogue" | Madonna | |
| June 16 | "Hold On" | Wilson Phillips | |
| June 23 | "Step By Step" | New Kids On The Block | |
| June 30 | |||
| July 7 | |||
| July 14 | |||
| July 21 | |||
| July 28 | "She Ain't Worth It" | Glenn Medeiros featuring Bobby Brown | |
| August 4 | |||
| August 11 | "Vision of Love" | Mariah Carey | |
| August 18 | |||
| August 25 | "Come Back To Me" | Janet Jackson | |
| September 1 | "If Wishes Came True" | Sweet Sensation | |
| September 8 | "Blaze Of Glory" | Jon Bon Jovi | |
| September 15 | |||
| September 22 | "Thieves In The Temple" | Prince | |
| September 29 | |||
| October 6 | "(Can't Live Without Your) Love and Affection" | Nelson | |
| October 13 | "Praying For Time" | ||
| October 20 | |||
| October 27 | "I Don't Have The Heart" | James Ingram | |
| November 3 | "Ice Ice Baby" | ||
| November 10 | |||
| November 17 | "Love Takes Time" | Mariah Carey | |
| November 24 | |||
| December 1 | "I'm Your Baby Tonight" | Whitney Houston | |
| December 8 | |||
| December 15 | "Because I Love You (The Postman Song)" | Stevie B | |
| December 22 | |||
| December 29 | "Justify My Love" | Madonna |