These are the number-one hits on the Top 100 Singles chart in 1979 as published by Cash Box magazine.
| Indicates best-performing single of 1979 |
| Issue date | Song | Artist | |
|---|---|---|---|
| January 6 | bgcolor=#FFFF99 rowspan="4" | "Le Freak" | Chic |
| January 13 | |||
| January 20 | |||
| January 27 | |||
| February 3 | "Da Ya Think I'm Sexy?" | Rod Stewart | |
| February 10 | |||
| February 17 | |||
| February 24 | |||
| March 3 | |||
| March 10 | "I Will Survive" | Gloria Gaynor | |
| March 17 | "Tragedy" | ||
| March 24 | |||
| March 31 | |||
| April 7 | "What a Fool Believes" | Doobie Brothers | |
| April 14 | |||
| April 21 | "Knock on Wood" | Amii Stewart | |
| April 28 | "Heart of Glass" | Blondie | |
| May 5 | "Reunited" | Peaches & Herb | |
| May 12 | |||
| May 19 | |||
| May 26 | |||
| June 2 | "Hot Stuff" | Donna Summer | |
| June 9 | |||
| June 16 | |||
| June 23 | |||
| June 30 | "Ring My Bell" | Anita Ward | |
| July 7 | |||
| July 14 | |||
| July 21 | "Bad Girls" | Donna Summer | |
| July 28 | |||
| August 4 | |||
| August 11 | "Good Times" | Chic | |
| August 18 | "My Sharona" | The Knack | |
| August 25 | |||
| September 1 | |||
| September 8 | |||
| September 15 | |||
| September 22 | |||
| September 29 | "Sad Eyes" | Robert John | |
| October 6 | |||
| October 13 | "Don't Stop 'til You Get Enough" | Michael Jackson | |
| October 20 | "Sail On" | Commodores | |
| October 27 | "Rise" | Herb Alpert | |
| November 3 | |||
| November 10 | "Heartache Tonight" | Eagles | |
| November 17 | "Still" | Commodores | |
| November 24 | "Babe" | Styx | |
| December 1 | |||
| December 8 | |||
| December 15 | "No More Tears (Enough Is Enough)" | Barbra Streisand & Donna Summer | |
| December 22 | "Escape (The Pina Colada Song)" | Rupert Holmes | |
| December 29 | |||