These are the songs that reached number one on the Top 50 Best Sellers chart in 1952 as published by Cash Box magazine. Until October 25, 1952, artists were not specified in the charts of this period so songs may represent more than one version. The artist who most popularized each song is listed. Beginning October 25, Cash Box began tracking specific versions of songs and thus began listing the artists.
| Issue date | Song | Artist |
|---|---|---|
| January 5 | "(It's No) Sin" | Eddy Howard |
| January 12 | "Slow Poke" | (several different versions) |
| January 19 | ||
| January 26 | ||
| February 2 | "Cry" | Johnnie Ray |
| February 9 | ||
| February 16 | ||
| February 23 | ||
| March 1 | ||
| March 8 | ||
| March 15 | ||
| March 22 | ||
| March 29 | "Wheel of Fortune" | Kay Starr |
| April 5 | ||
| April 12 | ||
| April 19 | "Blue Tango" | Leroy Anderson |
| April 26 | ||
| May 3 | ||
| May 10 | "Wheel of Fortune" | Kay Starr |
| May 17 | "Blue Tango" | Leroy Anderson |
| May 24 | ||
| May 31 | "Kiss of Fire" | Georgia Gibbs |
| June 7 | ||
| June 14 | ||
| June 21 | ||
| June 28 | ||
| July 5 | ||
| July 12 | ||
| July 19 | ||
| July 26 | "Auf Wiederseh'n, Sweetheart" | Vera Lynn |
| August 2 | ||
| August 9 | ||
| August 16 | ||
| August 23 | ||
| August 30 | ||
| September 6 | ||
| September 13 | ||
| September 20 | ||
| September 27 | "You Belong to Me" | Jo Stafford |
| October 4 | ||
| October 11 | ||
| October 18 | ||
| October 25 | "I Went to Your Wedding" | Patti Page |
| November 1 | ||
| November 8 | ||
| November 15 | ||
| November 22 | ||
| November 29 | ||
| December 6 | "The Glow-Worm" | The Mills Brothers |
| December 13 | "Why Don't You Believe Me" | Joni James |
| December 20 | ||
| December 27 |