This is a list of singles that charted in the top ten of the Billboard Hot 100 during 2001.
Ja Rule and Destiny's Child each had four top-ten hits in 2001, tying them for the most top-ten hits during the year.
| Singles from 2000 | |||||
|---|---|---|---|---|---|
| November 18 | "The Way You Love Me" | Faith Hill | 6 | January 13 | 13 |
| December 2 | "It Wasn't Me" | Shaggy featuring Rikrok | 1 | February 3 | 16 |
| December 16 | "Ms. Jackson" | Outkast | 1 | February 17 | 12 |
| December 30 | "If You're Gone" (#6) | Matchbox Twenty | 5 | January 27 | 10 |
| "Dance with Me" | Debelah Morgan | 8 | January 6 | 3 | |
| Singles from 2001 | |||||
| January 6 | "Liquid Dreams" | O-Town | 10 | January 6 | 1 |
| January 20 | "Again" (#9) | Lenny Kravitz | 4 | February 17 | 14 |
| "Love Don't Cost a Thing" | Jennifer Lopez | 3 | February 24 | 10 | |
| February 3 | "Don't Tell Me" | Madonna | 4 | February 3 | 8 |
| "Stutter" | Joe featuring Mystikal | 1 | February 24 | 14 | |
| February 17 | "Angel" | Shaggy featuring Rayvon | 1 | March 31 | 14 |
| February 24 | "Put It on Me" | Ja Rule featuring Lil' Mo and Vita | 8 | March 24 | 7 |
| March 10 | "Butterfly" | Crazy Town | 1 | March 24 | 8 |
| "It's Over Now" | 112 | 6 | March 17 | 3 | |
| "Promise" | Jagged Edge | 9 | March 10 | 3 | |
| March 24 | "All for You" (#3) | Janet Jackson | 1 | April 14 | 14 |
| March 31 | "Thank You" (#8) | Dido | 3 | April 28 | 11 |
| "Survivor" | Destiny's Child | 2 | April 14 | 11 | |
| bgcolor = #99FFFF | "Get Over Yourself" | Eden's Crush | 8 | March 31 | 3 |
| "Jaded" | Aerosmith | 7 | April 7 | 3 | |
| April 14 | "Missing You" | Case | 4 | April 28 | 5 |
| "Stranger in My House" | Tamia | 10 | April 14 | 2 | |
| April 21 | "Hanging by a Moment" (#1) | Lifehouse | 2 | June 16 | 20 |
| April 28 | "Ride wit Me" | Nelly featuring City Spud | 3 | June 23 | 12 |
| May 5 | "Follow Me" | Uncle Kracker | 5 | June 9 | 8 |
| "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa and Pink | 1 | June 2 | 12 | |
| May 12 | "Never Had a Dream Come True" | S Club 7 | 10 | May 12 | 2 |
| May 19 | "What Would You Do?" | City High | 8 | May 26 | 4 |
| May 26 | "I'm Like a Bird" | Nelly Furtado | 9 | May 26 | 1 |
| "Get Ur Freak On" | Missy Elliott | 7 | June 30 | 7 | |
| June 2 | "Fiesta" | R. Kelly featuring Jay-Z | 6 | June 23 | 6 |
| June 9 | "My Baby" | Lil' Romeo | 3 | June 30 | 5 |
| June 16 | "Drops of Jupiter (Tell Me)" (#4) | Train | 5 | June 23 | 14 |
| "Peaches & Cream" | 112 | 4 | July 7 | 8 | |
| June 30 | "Let Me Blow Ya Mind" (#7) | Eve featuring Gwen Stefani | 2 | August 18 | 17 |
| "There You'll Be" | Faith Hill | 10 | June 30 | 1 | |
| July 7 | "U Remind Me" | Usher | 1 | July 7 | 16 |
| July 14 | "Hit 'Em Up Style (Oops!)" | Blu Cantrell | 2 | July 21 | 16 |
| "Bootylicious" | Destiny's Child | 1 | August 4 | 6 | |
| "Drive" | Incubus | 9 | July 28 | 3 | |
| July 21 | "All or Nothing" | O-Town | 3 | July 28 | 6 |
| August 4 | "Loverboy" | Mariah Carey featuring Cameo | 2 | August 4 | 3 |
| "Fallin'" (#2) | Alicia Keys | 1 | August 18 | 19 | |
| August 11 | "I'm Real" (#5) | Jennifer Lopez featuring Ja Rule | 1 | September 8 | 19 |
| "Where the Party At" | Jagged Edge featuring Nelly | 3 | September 15 | 13 | |
| August 25 | "It's Been Awhile" | Staind | 5 | October 20 | 12 |
| September 1 | "Someone to Call My Lover" | Janet Jackson | 3 | September 1 | 6 |
| September 22 | "Family Affair" | Mary J. Blige | 1 | November 3 | 19 |
| "You Rock My World" | Michael Jackson | 10 | September 22 | 1 | |
| September 29 | "Izzo (H.O.V.A.)" | Jay-Z | 8 | October 20 | 5 |
| October 13 | "Differences" | Ginuwine | 4 | October 27 | 15 |
| October 27 | "The Star Spangled Banner" | Whitney Houston | 6 | October 27 | 1 |
| "Hero" | Enrique Iglesias | 3 | November 17 | 14 | |
| November 3 | "Turn Off the Light" | Nelly Furtado | 5 | November 10 | 8 |
| "U Got It Bad" | Usher | 1 | December 15 | 20 | |
| "Livin' It Up" | Ja Rule featuring Case | 6 | December 8 | 9 | |
| November 10 | "Only Time" | Enya | 10 | November 10 | 3 |
| November 17 | "How You Remind Me" | Nickelback | 1 | December 22 | 23 |
| December 1 | "Emotion" | Destiny's Child | 10 | December 1 | 1 |
| December 8 | "Get the Party Started" | Pink | 4 | December 29 | 12 |
| December 15 | "Whenever, Wherever" | Shakira | 6 | December 29 | 8 |
See main article: article and List of Billboard Hot 100 top-ten singles in 2000.
| September 30 | "With Arms Wide Open" | Creed | 1 | November 11 | 18 |
| November 4 | "This I Promise You" | 'N Sync | 5 | December 2 | 9 |
| "Independent Women Part I" (#10) | Destiny's Child | 1 | November 18 | 17 | |
| "Case of the Ex" | Mýa | 2 | December 2 | 13 | |
| December 16 | "He Loves U Not" | Dream | 2 | December 30 | 11 |
See main article: article and List of Billboard Hot 100 top-ten singles in 2002.
| December 22 | "Always on Time" | Ja Rule featuring Ashanti | 1 | February 23 | 16 |
| December 29 | "My Sacrifice" | Creed | 4 | February 9 | 11 |