This is a list of singles that charted in the top ten of the Billboard Global 200, an all-genre singles chart, in 2022.
Key
| Weeks in top ten | |||||||
| "Save Your Tears" (#10) | The Weeknd | 1 | 35 | ||||
| "Bad Habits" (#8) | Ed Sheeran | 1 | 30 | ||||
| "Stay" (#3) | The Kid Laroi and Justin Bieber | 1 | 43 | ||||
| "Industry Baby" | Lil Nas X and Jack Harlow | 2 | 22 | ||||
| "Take My Breath" | The Weeknd | 5 | 2 | ||||
| "Pepas" | Farruko | 7 | 10 | ||||
| "Shivers" (#5) | Ed Sheeran | 3 | 31 | ||||
| "Easy on Me" (#6) | Adele | 1 | 20 |
| Weeks in top ten | |||||||
| "Calm Down" | Rema and Selena Gomez | 3 | 33 | ||||
| "Karma" | Taylor Swift featuring Ice Spice | 6 | 2 | ||||
| "Kill Bill" | SZA | 1 | 21 |
| Weeks in top ten | ||||||
| "All I Want for Christmas Is You" | Mariah Carey | 1 | 16 | |||
| "Last Christmas" | Wham! | 2 | 15 | |||
| "Rockin' Around the Christmas Tree" | Brenda Lee | 2 | 14 | |||
| "Jingle Bell Rock" | Bobby Helms | 4 | 14 | |||
| "It's Beginning to Look a Lot Like Christmas" | Michael Buble | 6 | 7 | |||
| "Santa Tell Me" | Ariana Grande | 5 | 9 | |||
| "It's the Most Wonderful Time of the Year" | Andy Williams | 7 | 6 | |||
| "Feliz Navidad" | Jose Feliciano | 5 | 4 |
The Weeknd's "Take My Breath" re-entered the top ten at number 10 on January 22, 2022 upon the release of its parent album Dawn FM. The Dawn FM album version of "Take My Breath" is an extended version of the song.
The single re-entered the top ten on the week ending January 1, 2022.
The single re-entered the top ten on the week ending January 8, 2022.
The single re-entered the top ten on the week ending January 15, 2022.
The single re-entered the top ten on the week ending January 22, 2022.
The single re-entered the top ten on the week ending January 29, 2022.
The single re-entered the top ten on the week ending February 12, 2022.
The single re-entered the top ten on the week ending March 5, 2022.
The single re-entered the top ten on the week ending March 26, 2022.
The single re-entered the top ten on the week ending April 23, 2022.
The single re-entered the top ten on the week ending May 7, 2022.
The single re-entered the top ten on the week ending June 11, 2022.
The single re-entered the top ten on the week ending June 18, 2022.
The single re-entered the top ten on the week ending July 9, 2022.
The single re-entered the top ten on the week ending July 16, 2022.
The single re-entered the top ten on the week ending July 23, 2022.
The single re-entered the top ten on the week ending August 13, 2022.
The single re-entered the top ten on the week ending August 27, 2022.
The single re-entered the top ten on the week ending October 15, 2022.
The single re-entered the top ten on the week ending October 22, 2022.
The single re-entered the top ten on the week ending November 12, 2022.
The single re-entered the top ten on the week ending November 26, 2022.
The single re-entered the top ten on the week ending December 3, 2022.
The single re-entered the top ten on the week ending December 10, 2022.
The single re-entered the top ten on the week ending December 17, 2022.
The single re-entered the top ten on the week ending December 24, 2022.
The single re-entered the top ten on the week ending December 31, 2022.