This is a list of the United States Billboard Dance Club Songs number-one hits of 2016.
| Indicates most-played song of 2016. |
| Issue date | Song | Artist(s) | Ref. | |
|---|---|---|---|---|
| scope=row | January 2 | "Run on Love" | Lucas Nord featuring Tove Lo | [1] |
| scope=row | January 9 | "Sorry" | Justin Bieber | [2] |
| scope=row | January 16 | "Higher Place" | Dimitri Vegas & Like Mike featuring Ne-Yo | [3] |
| scope=row | January 23 | "Til It Happens to You" | Lady Gaga | [4] |
| scope=row | January 30 | "Shout It Out Loud" | Robin S. and DJ Escape | [5] |
| scope=row | February 6 | "Magnets" | Disclosure featuring Lorde | [6] |
| scope=row | February 13 | "California Dreamin'" | Freischwimmer | [7] |
| scope=row | February 20 | "Stolen Car" | Mylène Farmer and Sting | [8] |
| scope=row | February 27 | "Over and Over Again" | Nathan Sykes featuring Ariana Grande | [9] |
| scope=row | March 5 | "The Girl Is Mine" | 99 Souls featuring Destiny's Child and Brandy | [10] |
| scope=row | March 12 | "True Original" | Dave Audé featuring Andy Bell | [11] |
| scope=row | March 19 | "Adventure of a Lifetime" | Coldplay | [12] |
| scope=row | March 26 | "When We Were Young" | Adele | [13] |
| scope=row | April 2 | "Sound of Your Heart" | Shawn Hook | [14] |
| scope=row | April 9 | "Fast Car" | Jonas Blue featuring Dakota | [15] |
| scope=row | April 16 | "Youth" | Troye Sivan | [16] |
| scope=row | April 23 | "Work" | Rihanna featuring Drake | [17] |
| scope=row | April 30 | "The Pop Kids" | Pet Shop Boys | [18] |
| scope=row | May 7 | "If You Like It" | StoneBridge featuring Elsa Li Jones | [19] |
| scope=row | May 14 | "Walking on a Dream" | Empire of the Sun | [20] |
| scope=row | May 21 | "One Night" | WTS featuring Gia | [21] |
| scope=row | May 28 | "Smile" | Sheila Gordhan | [22] |
| scope=row | June 4 | "So Happy" | Tony Moran featuring Jason Walker | [23] |
| scope=row | June 11 | "Coming Over" | Dillon Francis and Kygo featuring James Hersey | [24] |
| scope=row | June 18 | "Under These Lights" | Xenia Ghali | [25] |
| scope=row | June 25 | "Cheap Thrills" | Sia featuring Sean Paul | [26] |
| scope=row | July 2 | "Kill the Lights" | Alex Newell, Jess Glynne and DJ Cassidy with Nile Rodgers | [27] |
| scope=row | July 9 | "This Is What You Came For" | Calvin Harris featuring Rihanna | [28] |
| scope=row | July 16 | [29] | ||
| scope=row | July 23 | "Can't Stop the Feeling!" | Justin Timberlake | [30] |
| scope=row | July 30 | "Livin' for Your Love (Your Love)" | Rosabel featuring Jeanie Tracy | [31] |
| scope=row | August 6 | "Kiss It Better" | Rihanna | [32] |
| scope=row | August 13 | "How Many Fucks" | Erika Jayne | [33] |
| scope=row | August 20 | "Needed Me" | Rihanna | [34] |
| scope=row | August 27 | "Sunrise" | Joe Bermudez featuring Louise Carver | [35] |
| scope=row | September 3 | "Like I Would" | Zayn | [36] |
| scope=row | September 10 | "Sweet Dreams" | JX Riders featuring Skylar Stecker | [37] |
| scope=row | September 17 | "Duele el Corazón" | Enrique Iglesias featuring Wisin | [38] |
| scope=row | September 24 | "Cold Water" | Major Lazer featuring Justin Bieber and MØ | [39] |
| scope=row | October 1 | "Boss" | Disclosure | [40] |
| scope=row | October 8 | "Make Me..." | Britney Spears featuring G-Eazy | [41] |
| scope=row | October 15 | "In Common" | Alicia Keys | [42] |
| scope=row | October 22 | "Rise" | Katy Perry | [43] |
| scope=row | October 29 | "Put 'Em High (2016)" | StoneBridge featuring Therese | [44] |
| scope=row | November 5 | "I Love You Always Forever" | Betty Who | [45] |
| scope=row | November 12 | "Telepathy" | Christina Aguilera featuring Nile Rodgers | [46] |
| scope=row | November 19 | "Perfect Strangers" | Jonas Blue featuring JP Cooper | [47] |
| scope=row | November 26 | "Believe" | Crystal Waters featuring Sted-E and Hybrid Heights | [48] |
| scope=row | December 3 | "People Grinnin'" | Nervo featuring The Child of Lov | [49] |
| scope=row | December 10 | "In the Name of Love" | Martin Garrix and Bebe Rexha | [50] |
| scope=row | December 17 | "Say Yes" | Tony Moran featuring Jason Walker | [51] |
| scope=row | December 24 | "Icarus" | R3hab | [52] |
| scope=row | December 31 | "Button Pusha" | Ralphi Rosario featuring Aneeta Beat | [53] |