| Post: | United States Assistant Secretary of State for Educational and Cultural Affairs |
| Insignia: | U.S. Department of State official seal.svg |
| Insigniasize: | 120px |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Lee Satterfield |
| Incumbentsince: | November 23, 2021 |
| Reports To: | The Under Secretary for Public Diplomacy and Public Affairs |
| Nominator: | The President of the United States |
| Formation: | 1961 |
| Inaugural: | Philip Hall Coombs |
The Assistant Secretary of State for Educational and Cultural Affairs is the head of the Bureau of Educational and Cultural Affairs, a bureau within the United States Department of State. The Assistant Secretary of State for Educational and Cultural Affairs reports to the Under Secretary of State for Public Diplomacy and Public Affairs.
Note: the post had been abolished from 1978 to 1999. In 1978 the Bureau was abolished and its functions transferred to the International Communications Agency (subsequently the United States Information Agency) under Reorganization Plan No. 2 (91 Stat. 1637). On October 1, 1999, pursuant to the integration of the U.S. Information Agency into the Department of State this position was revived.
| Name | Assumed office | Left office | President(s) served under | |
|---|---|---|---|---|
| 1 | Philip Hall Coombs | March 23, 1961 | June 4, 1962 | John F. Kennedy |
| 2 | Lucius D. Battle | June 5, 1962 | August 20, 1964 | John F. Kennedy, Lyndon B. Johnson |
| 3 | Harry McPherson | August 23, 1964 | August 14, 1965 | Lyndon B. Johnson |
| 4 | Charles Frankel | September 15, 1965 | December 31, 1967 | |
| 5 | Edward D. Re | February 28, 1968 | January 9, 1969 | |
| 6 | John Richardson Jr. | July 15, 1969 | March 7, 1977 | Richard Nixon, Gerald Ford |
| 7 | April 8, 1977 | March 21, 1978 | Jimmy Carter | |
| 8 | Alice Stone Ilchman | March 22, 1978 | March 31, 1978 | |
| - | Position abolished | |||
| 9 | November 18, 1999 | January 20, 2001 | Bill Clinton | |
| 10 | Patricia Harrison | October 2, 2001 | July 1, 2005 | George W. Bush |
| 11 | Dina Powell | July 11, 2005 | June 7, 2007 | |
| 12 | Goli Ameri | March 19, 2008 | January 20, 2009 | |
| 13 | Ann Stock | June 23, 2010 | August 16, 2013 | Barack Obama |
| 14 | Evan Ryan | September 26, 2013 | January 6, 2017 | |
| - | Mark Taplin (acting) | January 2017 | August 2017 | Donald Trump |
| - | Jennifer Zimdahl Galt (acting) | November 13, 2017 | March 29, 2018 | |
| 15 | Marie Royce[1] | March 30, 2018[2] | January 20, 2021 | |
| - | Matthew Lussenhop (acting) | January 20, 2021 | November 22, 2021 | Joe Biden |
| 16 | Lee Satterfield | November 23, 2021 | present |