This is a list of films which have placed number one at the weekly box office in Italy during 2012.
| Date | Film | Total Gross | Notes | |||
|---|---|---|---|---|---|---|
| 1 | Immaturi - Il viaggio | $15,512,578 | ||||
| 2 | Immaturi - Il viaggio | |||||
| 3 | Benvenuti al Nord | $33,498,625 | ||||
| 4 | Benvenuti al Nord | |||||
| 5 | Benvenuti al Nord | |||||
| 6 | Com'è bello far l'amore | $9,065,716 | ||||
| 7 | Com'è bello far l'amore | |||||
| 8 | $5,908,558 | |||||
| 9 | A Flat for Three | $11,398,541 | ||||
| 10 | A Flat for Three | |||||
| 11 | The Intouchables | $19,385,193 | ||||
| 12 | $3,731,609 | |||||
| 13 | Wrath of the Titans | $5,447,003 | ||||
| 14 | Titanic 3D | $9,847,064 | ||||
| 15 | Battleship | $5,747,869 | ||||
| 16 | To Rome with Love | $9,565,012 | ||||
| 17 | Marvel's The Avengers | $22,012,517 | ||||
| 18 | American Reunion | $7,878,279 | ||||
| 19 | Dark Shadows | $8,830,490 | ||||
| 20 | Dark Shadows | |||||
| 21 | Men in Black 3 | $7,671,850 | ||||
| 22 | Men in Black 3 | |||||
| 23 | Men in Black 3 | |||||
| 24 | The Dictator | $3,337,936 | ||||
| 25 | The Dictator | |||||
| 26 | The Dictator | |||||
| 27 | The Amazing Spider-Man | $15,502,063 | ||||
| 28 | Snow White and the Huntsman | $11,463,994 | ||||
| 29 | Snow White and the Huntsman | |||||
| 30 | Snow White and the Huntsman | |||||
| 31 | Snow White and the Huntsman | |||||
| 32 | Snow White and the Huntsman | |||||
| 33 | The Expendables 2 | $7,082,046 | ||||
| 34 | $28,057,921 | |||||
| 35 | Madagascar 3: Europe's Most Wanted | |||||
| 36 | The Dark Knight Rises | $18,801,748 | ||||
| 37 | Prometheus | $6,499,130 | ||||
| 38 | Magic Mike | $5,032,03 | ||||
| 39 | $21,459,516 | |||||
| 40 | Ice Age: Continental Drift | |||||
| 41 | Ted | $14,054,547 | ||||
| 42 | Ted | |||||
| 43 | Viva L'Italia | $6,880,371 | ||||
| 44 | Skyfall | $16,783,632 | ||||
| 45 | Skyfall | |||||
| 46 | $24,062,547 | |||||
| 47 | The Twilight Saga: Breaking Dawn Part 2 | |||||
| 48 | Rise of the Guardians | $5,788,535 | ||||
| 49 | Rise of the Guardians | |||||
| 50 | $10,666,115 |