This is a list of films which have placed number one at the weekend box office in Ecuador during 2012.
| Date | Film | Gross | Notes | |
|---|---|---|---|---|
| 1 | $734,121 | |||
| 2 | The Adventures of Tintin: The Secret of the Unicorn | $587,425 | ||
| 3 | The Muppets | $754,445 | ||
| 4 | $480,867 | |||
| 5 | $414,293 | |||
| 6 | $483,252 | |||
| 7 | $680,042 | |||
| 8 | $612,648 | |||
| 9 | $704,570 | |||
| 10 | John Carter | $690,604 | ||
| 11 | $590,056 | |||
| 12 | Beauty and the Beast | $691,550 | ||
| 13 | $591,776 | |||
| 14 | The Lorax | $733,874 | ||
| 15 | $372,959 | |||
| 16 | Wrath of the Titans | $702,420 | ||
| 17 | Marvel's The Avengers | $1,481,899 | ||
| 18 | $1,089,452 | |||
| 19 | $676,188 | |||
| 20 | $612,206 | |||
| 21 | Men in Black 3 | $817,882 | ||
| 22 | $854,973 | |||
| 23 | $854,511 | |||
| 24 | $831,355 | |||
| 25 | $747,630 | |||
| 26 | $1,212,422 | |||
| 27 | The Amazing Spider-Man | $1,226,712 | ||
| 28 | Ice Age: Continental Drift | $982,999 | ||
| 29 | $737,202 | |||
| 30 | The Dark Knight Rises | $923,464 | ||
| 31 | $703,369 | |||
| 32 | Brave | $1,039,703 | ||
| 33 | $634,283 | |||
| 34 | $514,020 | |||
| 35 | Secret of the Wings | $562,726 | ||
| 36 | The Apparition | $158,548 | ||
| 37 | $655,676 | |||
| 38 | $594,522 | |||
| 39 | $479,571 | |||
| 40 | Taken 2 | $469,391 | ||
| 41 | Frankenweenie | $663,901 | ||
| 42 | Hotel Transylvania | $604,777 | ||
| 43 | $575,235 | |||
| 44 | Skyfall | $800,935 | ||
| 45 | $487,854 | |||
| 46 | $1,003,809 | |||
| 47 | $624,011 | |||
| 48 | Rise of the Guardians | $537,875 | ||
| 49 | $481,455 | |||
| 50 | $213,412 | |||
| 51 | Life of Pi | $420,130 | ||
| 52 | $622,193 | |||