This is a list of films which have placed number one at the weekend box office in Venezuela during 2010.
| Date | Film | Gross | Notes | |
|---|---|---|---|---|
| 1 | Avatar | $764,134 | ||
| 2 | Avatar | $804,602 | ||
| 3 | Avatar | $321,233 | ||
| 4 | Tooth Fairy | $240,675 | ||
| 5 | Tooth Fairy | $238,526 | ||
| 6 | Old Dogs | $273,396 | ||
| 7 | $240,668 | |||
| 8 | Old Dogs | $234,797 | ||
| 9 | Old Dogs | $220,241 | ||
| 10 | Alice in Wonderland | $628,604 | ||
| 11 | Alice in Wonderland | $602,006 | ||
| 12 | Alice in Wonderland | $493,098 | ||
| 13 | Alice in Wonderland | $291,301 | ||
| 14 | How to Train Your Dragon | $271,301 | ||
| 15 | Date Night | $198,981 | ||
| 16 | Clash of the Titans | $536,976 | ||
| 17 | Clash of the Titans | $439,711 | ||
| 18 | Iron Man 2 | $418,341 | ||
| 19 | Iron Man 2 | $236,187 | ||
| 20 | A Nightmare on Elm Street | $270,756 | ||
| 21 | A Nightmare on Elm Street | $254,536 | ||
| 22 | Marmaduke | $201,269 | ||
| 23 | Robin Hood | $272,388 | ||
| 24 | Robin Hood | $203,329 | ||
| 25 | Toy Story 3 | $729,863 | ||
| 26 | Toy Story 3 | $749,985 | ||
| 27 | $711,187 | |||
| 28 | Shrek Forever After | $682,613 | ||
| 29 | Shrek Forever After | $741,401 | ||
| 30 | Shrek Forever After | $614,024 | ||
| 31 | Shrek Forever After | $470,193 | ||
| 32 | The Karate Kid | $409,123 | ||
| 33 | Despicable Me | $465,730 | ||
| 34 | Despicable Me | $407,667 | ||
| 35 | The Last Airbender | $420,004 | ||
| 36 | The Sorcerer's Apprentice | $465,730 | ||
| 37 | $440,431 | |||
| 38 | Resident Evil: Afterlife | $368,845 | ||
| 39 | Resident Evil: Afterlife | $199,699 | ||
| 40 | $332,234 | |||
| 41 | Legend of the Guardians: The Owls of Ga'Hoole | $281,138 | ||
| 42 | Legend of the Guardians: The Owls of Ga'Hoole | $194,044 | ||
| 43 | La Hora Cero | $174,838 | ||
| 44 | Saw 3D | $250,576 | ||
| 45 | Paranormal Activity 2 | $197,020 | ||
| 46 | Life as We Know It | $179,213 | ||
| 47 | Harry Potter and the Deathly Hallows – Part 1 | $940,949 | Harry Potter and the Deathly Hallows – Part 1 had the highest weekend debut of 2010. | |
| 48 | Tangled | $687,730 | ||
| 49 | Tangled | $718,219 | ||
| 50 | Megamind | $455,096 | ||
| 51 | $465,499 | |||
| 52 | Tron: Legacy | $348,980 | ||
| 53 | Tron: Legacy | $225,720 | ||
| Rank | Title | Studio | Domestic Gross | |
|---|---|---|---|---|
| 1. | Tangled | Walt Disney Pictures | $6,863,748 | |
| 2. | Toy Story 3 | Walt Disney Pictures / Pixar Animation Studios | $6,339,322 | |
| 3. | Shrek Forever After | Paramount Pictures / DreamWorks Animation | $5,984,037 | |
| 4. | Harry Potter and the Deathly Hallows – Part 1 | Warner Bros. / Heyday Films | $4,743,014 | |
| 5. | Alice in Wonderland | Walt Disney Pictures | $4,335,113 | |
| 6. | La Hora Cero | Centro Nacional Autónomo de Cinematografía | $3,947,360 | |
| 7. | Walt Disney Pictures | $3,419,740 | ||
| 8. | Summit Entertainment | $3,220,661 | ||
| 9. | Clash of the Titans | Warner Bros. | $3,010,415 | |
| 10. | The Karate Kid | Columbia Pictures | $2,638,033 |