This is a list of films which have placed number one at the weekend box office in Spain during 2010.[1]
| Date | Film | Gross in euros | Gross in US dollars | Notes | ||
|---|---|---|---|---|---|---|
| 1 | Avatar (3) | €6,705,312 | $9,649,320 | It was Avatars third week at number one. | ||
| 2 | Avatar (4) | €4,650,728 | $6,704,235 | Avatar became the highest-grossing film in Spain of all time.[2] | ||
| 3 | Avatar (5) | €4,342,660 | $6,249,331 | |||
| 4 | Avatar (6) | €3,994,297 | $5,648,045 | |||
| 5 | Avatar (7) | €3,641,889 | $5,050,393 | |||
| 6 | Avatar (8) | €3,037,379 | $4,156,182 | |||
| 7 | Avatar (9) | €2,343,026 | $3,195,398 | |||
| 8 | Shutter Island | €2,438,309 | $3,320,228 | |||
| 9 | Shutter Island (2) | €1,625,337 | $2,215,926 | |||
| 10 | The Men Who Stare at Goats | €1,354,341 | $1,846,007 | |||
| 11 | Green Zone | €1,117,164 | $1,538,751 | |||
| 12 | The Book of Eli | €1,377,132 | $1,864,214 | |||
| 13 | How to Train Your Dragon | €1,787,792 | $2,394,033 | |||
| 14 | Clash of the Titans | €4,121,454 | $5,565,171 | |||
| 15 | Clash of the Titans (2) | €1,678,598 | $2,266,875 | |||
| 16 | Alice in Wonderland | €7,613,995 | $10,283,762 | Alice in Wonderland had the highest weekend debut of 2010. | ||
| 17 | Alice in Wonderland (2) | €4,225,262 | $5,655,096 | |||
| 18 | Alice in Wonderland (3) | €2,759,010 | $3,668,214 | |||
| 19 | Alice in Wonderland (4) | €1,835,074 | $2,342,000 | |||
| 20 | Robin Hood | €3,619,396 | $4,475,075 | |||
| 21 | Prince of Persia: The Sands of Time | €2,400,479 | $3,019,433 | |||
| 22 | Prince of Persia: The Sands of Time (2) | €1,641,834 | $2,015,856 | |||
| 23 | Sex and the City 2 | €1,460,892 | $1,749,089 | |||
| 24 | Prince of Persia: The Sands of Time (3) | €955,268 | $1,157,480 | Prince of Persia: The Sands of Time reclaimed #1 in its fourth weekend of release. | ||
| 25 | €722,937 | $894,447 | Marmaduke had the lowest number-one weekend debut of 2010. | |||
| 26 | Marmaduke (2) | €502,723 | $622,090 | The second weekend of Marmaduke had the lowest number-one weekend of 2010. | ||
| 27 | €5,260,905 | $6,613,497 | ||||
| 28 | Shrek Forever After | €3,249,149 | $4,108,634 | |||
| 29 | Shrek Forever After (2) | €3,385,900 | $4,379,641 | |||
| 30 | Toy Story 3 | €4,049,875 | $5,230,639 | |||
| 31 | Toy Story 3 (2) | €2,789,135 | $3,641,358 | |||
| 32 | Inception | €3,402,776 | $4,520,400 | |||
| 33 | Inception (2) | €2,190,265 | $2,794,561 | |||
| 34 | Salt | €1,941,164 | $2,468,292 | |||
| 35 | The Karate Kid | €2,993,255 | $3,821,827 | |||
| 36 | The Sorcerer's Apprentice | €1,712,757 | $2,209,553 | |||
| 37 | €2,651,992 | $3,364,447 | ||||
| 38 | The American | €1,200,073 | $1,566,757 | |||
| 39 | Eat Pray Love | €1,493,574 | $2,015,891 | |||
| 40 | Vampires Suck | €1,114,715 | $1,537,856 | |||
| 41 | Despicable Me | €2,467,220 | $3,439,976 | |||
| 42 | Despicable Me (2) | €1,603,187 | $2,241,592 | |||
| 43 | Despicable Me (3) | €961,387 | $1,342,176 | |||
| 44 | Los ojos de Julia | €1,601,321 | $2,234,142 | |||
| 45 | Los ojos de Julia (2) | €1,119,884 | $1,571,922 | |||
| 46 | Unstoppable | €1,157,502 | $1,585,272 | |||
| 47 | Harry Potter and the Deathly Hallows – Part 1 | €5,898,426 | $8,067,768 | |||
| 48 | Harry Potter and the Deathly Hallows – Part 1 (2) | €2,759,993 | $3,656,104 | |||
| 49 | €2,141,435 | $2,874,139 | ||||
| 50 | The Chronicles of Narnia: The Voyage of the Dawn Treader (2) | €1,662,550 | $2,199,839 | |||
| 51 | €1,252,788 | $1,652,886 | ||||
| 52 | Little Fockers | €1,976,127 | $2,594,091 |
| 1. | Toy Story 3 | Disney | Lee Unkrich | United States | $33,154,762 | ||
| 2. | Alice in Wonderland | Disney | Tim Burton | United States | $28,769,165 | ||
| 3. | Aurum | David Slade | United States | $25,050,394 | |||
| 4. | Inception | Warner Bros. | Christopher Nolan | United Kingdom United States | $22,212,764 | ||
| 5. | Shrek Forever After | Paramount | Mike Mitchell | United States | $21,928,719 | ||
| 6. | Harry Potter and the Deathly Hallows – Part 1 | Warner Bros. | David Yates | United Kingdom United States | $19,017,186 | ||
| 7. | The King's Speech | DeAPlaneta | Tom Hooper | United Kingdom | $15,863,460 | ||
| 8. | Fox | Michael Apted | United Kingdom United States | $14,992,713 | |||
| 9. | Clash of the Titans | Warner Bros. | Louis Leterrier | United States United Kingdom | $14,556,322 | ||
| 10. | Despicable Me | Universal | Pierre Coffin & Chris Renaud | United States | $14,257,017 |