This is a list of films which have placed number one at the weekend box office in Italy during 2010.
| Date | Film | Weekend Gross | Total Gross | |
|---|---|---|---|---|
| 1 | Sherlock Holmes | $6,582,433 | $26,955,437 | |
| 2 | Io, Loro e Lara | $6,753,283 | $21,347,896 | |
| 3 | Avatar | $13,889,941 | $83,498,193 | |
| 4 | Avatar | $12,383,549 | ||
| 5 | Avatar | $10,357,947 | ||
| 6 | Avatar | $7,783,01 | ||
| 7 | Avatar | $5,181,248 | ||
| 8 | Avatar | $3,767,803 | ||
| 9 | Genitori & figli. Agitare bene prima dell'uso | $3,802,776 | $11,455,266 | |
| 10 | Alice in Wonderland | $11,115,961 | $39,952,697 | |
| 11 | Alice in Wonderland | $8,311,436 | ||
| 12 | Alice in Wonderland | $4,307,666 | ||
| 13 | How to Train Your Dragon | $1,630,412 | $9,979,666 | |
| 14 | La vita è una cosa meravigliosa | $2,287,044 | $6,161,728 | |
| 15 | The Ghost Writer | $1,382,472 | $4,811,454 | |
| 16 | Clash of the Titans | $4,286,144 | $10,275,464 | |
| 17 | Clash of the Titans | $2,133,330 | ||
| 18 | Iron Man 2 | $4,701,280 | $9,979,666 | |
| 19 | Iron Man 2 | $2,073,896 | ||
| 20 | Robin Hood | $5,172,957 | $14,676,791 | |
| 21 | Prince of Persia: The Sands of Time | $1,909,536 | $8,912,558 | |
| 22 | Sex and the City 2 | $2,072,658 | $7,802,889 | |
| 23 | Sex and the City 2 | $896,600 | ||
| 24 | The Hole | $495,714 | $2,094,728 | |
| 25 | The A-Team | $1,111,167 | $3,143,928 | |
| 26 | The A-Team | $396,533 | ||
| 27 | $4,793,904 | $20,711,944 | ||
| 28 | Toy Story 3 | $3,021,009 | $18,855,881 | |
| 29 | Toy Story 3 | $2,011,511 | ||
| 30 | Toy Story 3 | $1,245,241 | ||
| 31 | Toy Story 3 | $838,708 | ||
| 32 | Toy Story 3 | $500,852 | ||
| 33 | Marmaduke | $940,960 | $2,503,450 | |
| 34 | The Sorcerer's Apprentice | $16,968,032 | $9,571,490 | |
| 35 | Shrek Forever After | $4,504,291 | $23,451,561 | |
| 36 | Shrek Forever After | $3,637,448 | ||
| 37 | Shrek Forever After | $1,915,433 | ||
| 38 | Vampires Suck | $2,483,735 | $6,000,711 | |
| 39 | Inception | $3,556,167 | $15,459,083 | |
| 40 | Benvenuti al Sud | $5,231,564 | $43,015,634 | |
| 41 | Benvenuti al Sud | $6,242,77 | ||
| 42 | Benvenuti al Sud | $5,528,640 | ||
| 43 | Benvenuti al Sud | $3,889,528 | ||
| 44 | Maschi contro femmine | $4,222,767 | $18,452,860 | |
| 45 | Maschi contro femmine | $3,582,226 | ||
| 46 | Maschi contro femmine | $1,869,690 | ||
| 47 | Harry Potter and the Deathly Hallows – Part 1 | $10,193,771 | $23,988,197 | |
| 48 | Harry Potter and the Deathly Hallows - Part 1 | $4,625,564 | ||
| 49 | Tangled | $2,710,588 | $14,670,362 | |
| 50 | Tangled | $1,918,925 | ||
| 51 | Natale in Sud Africa | $4,282,724 | $24,898,572 | |
| 52 | Natale in Sud Africa | $8,073,079 | ||
| 53 | La banda dei babbi natale | $5,763,680 | $29,125,119 | |