This is a list of films which have placed number one at the weekend box office in Ecuador during 2010.
| Date | Film | Gross | Notes | |
|---|---|---|---|---|
| 1 | Avatar | $736,385 | ||
| 2 | $451,345 | |||
| 3 | $508,987 | |||
| 4 | Sherlock Holmes | $433,731 | ||
| 5 | Tooth Fairy | $398,819 | ||
| 6 | $426,616 | |||
| 7 | Old Dogs | $439,357 | ||
| 8 | $436,406 | |||
| 9 | $396,496 | |||
| 10 | Alice in Wonderland | $704,221 | ||
| 11 | $569,062 | |||
| 12 | $464,520 | |||
| 13 | How to Train Your Dragon | $521,133 | ||
| 14 | $583,918 | |||
| 15 | $417,340 | |||
| 16 | $398,773 | |||
| 17 | Clash of the Titans | $595,439 | ||
| 18 | Iron Man 2 | $736,811 | ||
| 19 | $498,791 | |||
| 20 | $465,965 | |||
| 21 | A Nightmare on Elm Street | $539,696 | ||
| 22 | Prince of Persia: The Sands of Time | $579,108 | ||
| 23 | $513,227 | |||
| 24 | $420,131 | |||
| 25 | Toy Story 3 | $834,571 | ||
| 26 | $691,137 | |||
| 27 | $595,762 | |||
| 28 | Shrek Forever After | $751,941 | ||
| 29 | $968,460 | |||
| 30 | Shrek Forever After | $804,864 | ||
| 31 | Despicable Me | $698,491 | ||
| 32 | $569,453 | |||
| 33 | The Karate Kid | $595,764 | ||
| 34 | $505,467 | |||
| 35 | The Karate Kid | $112,399 | ||
| 36 | Cats & Dogs: The Revenge of Kitty Galore | $409,378 | ||
| 37 | $522,153 | |||
| 38 | $462,223 | |||
| 39 | $388,923 | |||
| 40 | $342,583 | |||
| 41 | Piranha 3D | $342,608 | ||
| 42 | $281,176 | |||
| 43 | $291,135 | |||
| 44 | $85,503 | |||
| 45 | Legend of the Guardians: The Owls of Ga'Hoole | $221,972 | ||
| 46 | Harry Potter and the Deathly Hallows – Part 1 | $671,374 | ||
| 47 | $516,750 | |||
| 48 | $537,158 | |||
| 49 | $405,851 | |||
| 50 | $591,938 | |||
| 51 | $590,510 |