This is a list of films which have placed number one at the weekend box office in Spain during 2008.
| Date | Film | Gross in euros | Gross in US dollars | Notes | ||
|---|---|---|---|---|---|---|
| 1 | American Gangster (2) | $2,015,633 | ||||
| 2 | $2,356,965 | |||||
| 3 | The Oxford Murders | $3,270,522 | ||||
| 4 | Mortadelo y Filemón. Misión: salvar la Tierra | $4,257,686 | ||||
| 5 | Mortadelo y Filemón. Misión: salvar la Tierra (2) | $2,673,965 | ||||
| 6 | Astérix aux Jeux Olympiques | $2,797,276 | ||||
| 7 | Jumper | $3,779,660 | ||||
| 8 | Jumper (2) | $2,248,675 | ||||
| 9 | Vantage Point | $2,210,389 | ||||
| 10 | 10,000 BC | $4,541,070 | ||||
| 11 | 10,000 BC (2) | €1,350,611 | $2,116,282 | |||
| 12 | Horton Hears a Who! | €1,652,835 | $2,550,278 | Horton Hears a Who! reached #1 in its second weekend of release | ||
| 13 | Meet the Spartans | €1,878,601 | $2,966,369 | |||
| 14 | Meet the Spartans (2) | €1,025,645 | $1,613,665 | |||
| 15 | 21 | €1,204,500 | $1,903,445 | |||
| 16 | 21 (2) | €893,787 | $1,413,325 | |||
| 17 | Street Kings | €695,768 | $1,087,138 | Street Kings had the lowest weekend debut of 2008. | ||
| 18 | Iron Man | €2,184,427 | $3,368,430 | |||
| 19 | What Happens in Vegas | €2,443,672 | $3,782,188 | |||
| 20 | What Happens in Vegas (2) | €1,491,594 | $2,322,631 | |||
| 21 | Indiana Jones and the Kingdom of the Crystal Skull | €6,908,963 | $10,887,115 | Indiana Jones and the Kingdom of the Crystal Skull had the highest weekend debut of 2008. | ||
| 22 | Indiana Jones and the Kingdom of the Crystal Skull (2) | €4,041,919 | $6,285,055 | |||
| 23 | Indiana Jones and the Kingdom of the Crystal Skull (3) | €1,840,772 | $2,896,117 | |||
| 24 | The Happening | €2,235,325 | $3,436,846 | |||
| 25 | The Incredible Hulk | €1,419,385 | $2,214,674 | |||
| 26 | The Incredible Hulk (2) | €781,730 | $1,234,376 | |||
| 27 | €2,699,903 | $4,239,797 | ||||
| 28 | Kung Fu Panda | €3,928,838 | $6,259,101 | |||
| 29 | Hancock | €5,820,811 | $6,259,101 | |||
| 30 | Hancock (2) | €2,557,897 | $4,016,798 | |||
| 31 | €4,160,091 | $6,472,835 | ||||
| 32 | WALL-E | €2,133,483 | $3,200,544 | |||
| 33 | The Dark Knight | €3,016,685 | $4,429,137 | |||
| 34 | You Don't Mess with the Zohan | €2,303,052 | $3,405,371 | |||
| 35 | €2,096,889 | $3,075,970 | ||||
| 36 | The Argentine (Che: Part One) | €1,900,659 | $2,710,581 | |||
| 37 | Wanted | €2,269,313 | $3,227,582 | |||
| 38 | Vicky Cristina Barcelona | €2,237,385 | $3,235,553 | |||
| 39 | The Boy in the Striped Pyjamas | €2,223,937 | $3,248,520 | |||
| 40 | The Boy in the Striped Pyjamas (2) | €1,724,700 | $2,374,965 | |||
| 41 | Burn After Reading | €1,998,042 | $2,675,830 | |||
| 42 | Burn After Reading (2) | €1,313,618 | $1,760,646 | |||
| 43 | $5,649,631 | $5,649,631 | ||||
| 44 | High School Musical 3: Senior Year (2) | €1,975,203 | $2,512,022 | |||
| 45 | Body of Lies | €1,788,950 | $2,274,282 | |||
| 46 | Saw V | €2,230,353 | $2,815,036 | |||
| 47 | Quantum of Solace | €4,087,796 | $5,142,528 | |||
| 48 | €4,561,296 | $5,786,978 | ||||
| 49 | Twilight | €3,915,914 | $4,978,279 | |||
| 50 | The Day the Earth Stood Still | €2,134,031 | $2,856,420 | |||
| 51 | Changeling | €1,402,203 | $1,949,941 | |||
| 52 | Australia | €2,286,108 | $3,178,682 |