This is a list of films that placed number one at the weekend box office in Brazil during 2008. Amounts are in Brazilian reais (1 real is equivalent to approximately 0.64 US dollars).
| Date | Film | Gross | Notes |
|---|---|---|---|
| January 6 | The Golden Compass | R$1.809.205 | |
| January 13 | Meu Nome Não É Johnny | R$2.090.007 | Meu Nome Não é Johnny reached number-one in its second week of release. Highest-grossing Brazilian film of 2008. |
| January 20 | I Am Legend | R$4.991.476 | Most weeks at #1 in 2008. |
| January 27 | R$2.905.120 | ||
| February 3 | R$1.444.430 | ||
| February 10 | R$1.153.150 | ||
| February 17 | 27 Dresses | R$1.047.719 | |
| February 24 | Juno | R$1.410.950 | |
| March 2 | Rambo | R$1.261.748 | |
| March 9 | 10,000 BC | R$2.748.109 | |
| March 16 | Horton Hears a Who! | R$2.379.690 | |
| March 23 | R$1.530.593 | ||
| March 30 | Jumper | R$2.048.878 | |
| April 6 | R$1.484.585 | ||
| April 13 | R$832.847 | ||
| April 20 | Superhero Movie | R$2.005.801 | |
| April 27 | R$1.186.092 | ||
| May 4 | Iron Man | R$5.680.662 | |
| May 11 | R$3.004.645 | ||
| May 18 | R$2.467.399 | ||
| May 25 | Indiana Jones and the Kingdom of the Crystal Skull | R$6.038.139 | |
| June 1 | R$3.756.336 | ||
| June 8 | R$2.577.868 | ||
| June 15 | The Incredible Hulk | R$2.833.654 | |
| June 22 | Get Smart | R$2.026.300 | |
| June 29 | WALL-E | R$2.355.592 | |
| July 6 | Hancock | R$5.561.912 | |
| July 13 | R$3.346.785 | ||
| July 20 | The Dark Knight | R$7.102.500 | Highest-grossing film through 2008 |
| July 27 | R$4.992.475 | ||
| August 3 | R$4.872.112 | ||
| August 10 | R$1.154.427 | ||
| August 17 | R$1.799.329 | ||
| August 24 | Wanted | R$2.238.922 | |
| August 31 | R$1.385.025 | ||
| September 7 | R$1.355.060 | ||
| September 14 | Mamma Mia! | R$1.387.125 | |
| September 21 | R$1.097.697 | ||
| September 28 | Eagle Eye | R$861.225 | |
| October 5 | Disaster Movie | R$1.949.692 | |
| October 12 | Righteous Kill | R$1.471.596 | |
| October 19 | My Best Friend's Girl | R$1.091.019 | |
| October 26 | R$3.919.203 | ||
| November 2 | R$2.011.539 | ||
| November 9 | Quantum of Solace | R$4.746.672 | |
| November 16 | R$2.906.029 | ||
| November 23 | R$1.804.948 | ||
| November 30 | Burn After Reading | R$1.082.057 | |
| December 7 | R$737.876 | ||
| December 14 | R$7.501.787 | Biggest opening weekend of 2008; overall highest-grossing film of 2008 | |
| December 21 | R$4.438.606 | ||
| December 28 | R$3.585.993 |