| Date | Film | Gross (USD) | Openings in the top ten |
|---|
| 1 | | Night at the Museum | $2,167,918 | Stormbreaker (#7), (#9) |
| 2 | | Rocky Balboa | $1,609,380 | The Holiday (#3), Fuera del cielo (#4) |
| 3 | | Perfume: The Story of a Murderer | $1,559,476 | |
| 4 | | Apocalypto | $2,365,480 | Dreamgirls (#9) |
| 5 | | Kilómetro 31 | $1,508,862 | The Pursuit of Happyness (#3) |
| 6 | | $1,468,895 | Blood Diamond (#2), Employee of the Month (#8) |
| 7 | | Ghost Rider | $2,050,782 | Morirse en domingo (#7), Combien tu m'aimes? (#10) |
| 8 | | Norbit | $1,246,087 | Notes on a Scandal (#9) |
| 9 | | $773,988 | (#5), Freedom Writers (#10) |
| 10 | | Niñas Mal | $1,602,673 | Music and Lyrics (#2), The Fountain (#8) |
| 11 | | Epic Movie | $1,364,983 | Arthur and the Invisibles (#5), The Good Shepherd (#6) |
| 12 | | 300 | $2,585,419 | |
| 13 | | Meet the Robinsons | $1,877,402 | Shooter (#3), Cuando las cosas suceden (#6), Alatriste (#8), The Hills Have Eyes 2 (#10) |
| 14 | | Wild Hogs | $1,329,865 | The Reaping (#2), Mr. Bean's Holiday (#4), TMNT (#6), Are We Done Yet? (#7), The Queen (#10) |
| 15 | | $1,026,207 | (#5), The Number 23 (#10) |
| 16 | | Perfect Stranger | $940,938 | Disturbia (#4), Happily N'Ever After (#6), Primeval (#10) |
| 17 | | The Messengers | $674,664 | |
| 18 | | Spider-Man 3 | $12,002,306 | An American Haunting (#7) |
| 19 | | $6,118,161 | The Invisible (#2), Blades of Glory (#4) |
| 20 | | $2,997,567 | Premonition (#2) |
| 21 | | | $8,868,597 | |
| 22 | | $7,232,827 | 28 Weeks Later (#3), Zodiac (#5), My First Wedding (#8) |
| 23 | | $5,146,385 | Fracture (#2) |
| 24 | | Shrek the Third | $9,117,354 | |
| 25 | | | $5,676,476 | |
| 26 | | $3,143,520 | Ocean's Thirteen (#3) |
| 27 | | Ratatouille | $4,607,814 | Live Free or Die Hard (#2), Griffin & Phoenix (#9) |
| 28 | | Harry Potter and the Order of the Phoenix | $7,852,698 | (#7), |
| 29 | | Transformers | $5,457,346 | Lonely Hearts (#10) |
| 30 | | $3,048,772 | No Reservations (#4), Whisper (#6), La Niña en la piedra (#8), Hostel Part II (#9) |
| 31 | | The Simpsons Movie | $5,457,104 | Evan Almighty (#2), Alpha Dog (#9) |
| 32 | | $1,951,146 | Surf's Up (#2), License to Wed (#3), Hairspray (#6), Mr. Brooks (#7) |
| 33 | | $883,439 | Next (#3), El Búfalo de la Noche (#5), Vacancy (#7) |
| 34 | | Surf's Up | $620,760 | Knocked Up (#5), Breach (#6) |
| 35 | | Rush Hour 3 | $1,056,839 | |
| 36 | | The Bourne Ultimatum | $1,452,371 | Stardust (#2) |
| 37 | | Stardust | $790,715 | Bratz (#5) |
| 38 | | | $2,151,235 | Underdog (#2) |
| 39 | | I Now Pronounce You Chuck and Larry | $1,249,268 | The Invasion (#4) |
| 40 | | $986,395 | Superbad (#5), Catacombs (#8), A Mighty Heart (#9) |
| 41 | | The Game Plan | $1,915,281 | The Brave One (#2), Bad Habits (#5) |
| 42 | | $1,308,059 | (#2), Hasta el viento tiene miedo (#3), Michael Clayton (#9), 3:10 to Yuma (#10) |
| 43 | | $905,474 | 1408 (#2), Because I Said So (#5), The Kingdom (#8), Saw IV (#10) |
| 44 | | La Leyenda de la Nahuala | $1,479,685 | The Heartbreak Kid (#2), Halloween (#7) |
| 45 | | Bridge to Terabithia | $958,958 | Lions for Lambs (#3), Cascia (#10) |
| 46 | | $798,273 | Hannibal Rising (#6), (#7), Good Luck Chuck (#9) |
| 47 | | Beowulf | $1,931,957 | Dead Silence (#6), Rendition (#7) |
| 48 | | Bee Movie | $2,600,799 | Hitman (#3), 30 Days of Night (#4) |
| 49 | | $1,624,652 | Fred Claus (#2) |
| 50 | | Enchanted | $2,761,545 | The Golden Compass (#2), P2 (#7) |
| 51 | | Alvin and the Chipmunks | $1,651,829 | Sultanes del Sur (#4) |
| 52 | | | $2,397,296 | (#5), Love in the Time of Cholera (#6), Things We Lost in the Fire (#8) | |
