Lisinopril/hydrochlorothiazide explained

Verifiedrevid:447439314
Type:combo
Component1:Lisinopril
Class1:ACE inhibitor
Component2:Hydrochlorothiazide
Class2:Thiazide diuretic
Tradename:Zestoretic, Prinzide, others
Dailymedid:Lisinopril and hydrochlorothiazide
Pregnancy Category:Contraindicated
Routes Of Administration:By mouth
Atc Prefix:C09
Atc Suffix:BA03
Legal Ca:Rx-only
Legal Ca Comment:[1]
Legal Us:Rx-only
Legal Us Comment:[2]
Legal Status:Rx-only
Cas Number:151063-30-8
Kegg:D10268
Synonyms:lisinopril/hctz

Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). It contains lisinopril, an ACE inhibitor, and hydrochlorothiazide, a diuretic. Typically, it becomes an option once a person is doing well on the individual components. It is taken by mouth.

Common side effects include dizziness, headache, cough, and feeling tired. Severe side effects may include angioedema and low blood pressure. Use during pregnancy may harm the baby.

The combination was approved for medical use in the United States in 1989.[3] It is on the World Health Organization's List of Essential Medicines.[4] It is available as a generic medication.[5] In 2021, it was the 51st most commonly prescribed medication in the United States, with more than 12million prescriptions.[6] [7]

Medical uses

Lisinopril/hydrochlorothiazide is indicated for the treatment of hypertension, to lower blood pressure.

Adverse effects

The US Food and Drug Administration prescription label for the combination contains a boxed warning about harm to the baby.

Notes and References

  1. Web site: Product monograph brand safety updates . Health Canada . February 2024 . 24 March 2024.
  2. Web site: Zestoretic- lisinopril and hydrochlorothiazide tablet . DailyMed . 9 February 2022.
  3. Web site: Hydrochlorothiazide and lisinopril Uses, Side Effects & Warnings . Drugs.com . Cerner Multum . 26 December 2018 .
  4. Book: ((World Health Organization)) . The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) . 2023 . 10665/371090 . World Health Organization . World Health Organization . Geneva . WHO/MHP/HPS/EML/2023.02 . free .
  5. Book: British national formulary : BNF 74. 2017. British Medical Association. 978-0857112989. 166. 74.
  6. Web site: The Top 300 of 2021 . ClinCalc . 14 January 2024 . 15 January 2024 . https://web.archive.org/web/20240115223848/https://clincalc.com/DrugStats/Top300Drugs.aspx . live .
  7. Web site: Hydrochlorothiazide; Lisinopril - Drug Usage Statistics . ClinCalc . 14 January 2024.