| Honorific-Prefix: | Her Excellency |
| Lis Cuesta Peraza | |
| Office: | First Lady of Cuba |
| President: | Miguel Díaz-Canel |
| Term Label: | Assumed role |
| Term Start: | 19 April 2018 |
| Predecessor: | Vilma Espín (de facto, 2007) |
| Office1: | Second Lady of Cuba |
| Vicepresident1: | Miguel Díaz-Canel |
| Term Start1: | 24 February 2015 |
| Term End1: | 19 April 2018 |
| Predecessor1: | Position established |
| Successor1: | Julia Piloto Saborit |
| Birth Date: | 28 March 1971 |
| Birth Place: | Holguín, Cuba |
| Party: | Communist Party of Cuba (2009–present) |
| Children: | 2 |
| Alma Mater: | University of Holguín |
| Occupation: | Politician |
| Profession: | Tourism Executive |
Lis Cuesta Peraza de Díaz-Canel (born 28 March 1971) is a Cuban politician and former tourism executive who is the current First Lady of Cuba since 2018 as the second wife[1] of Miguel Díaz-Canel, the First Secretary of the Communist Party and President of Cuba. Cuesta is the first woman to be called "first lady" by Cuban state-run media since the 1960s.[2] [3] [4]