| Tradename: | Zefnart |
| Routes Of Administration: | Topical |
| Atc Prefix: | D01 |
| Atc Suffix: | AE25 |
| Legal Status: | JP: Rx-only |
| Cas Number: | 88678-31-3 |
| Pubchem: | 3936 |
| Chemspiderid: | 3799 |
| Unii: | 5253IGO5X3 |
| Kegg: | D01550 |
| Synonyms: | M-732; piritetrate |
| Iupac Name: | O-(5,6,7,8-Tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate |
| C: | 18 |
| H: | 20 |
| N: | 2 |
| O: | 2 |
| S: | 1 |
Liranaftate (trade name Zefnart) is a topical antifungal drug.[1] It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).[2] It was approved for use in Japan in August 2000.[3] [4]
Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.