| Liquiñe River | |
| Mouth Location: | Cua-Cua River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Chile |
The Liquiñe River is a river in the Andes of Los Ríos Region, Chile. The river is most known for the many hotsprings the upwell at its middle reaches where the town of Liquiñe is currently placed.