Limulus clotting factor B explained

Limulus clotting factor B
Ec Number:3.4.21.85
Cas Number:848851-53-6

Limulus clotting factor B is an enzyme.[1] This enzyme catalyses the following chemical reaction

Selective cleavage of -Arg98-Ile- bond in limulus proclotting enzyme to form active clotting enzyme

From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. This enzyme is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme.[2]

Notes and References

  1. Nakamura T, Horiuchi T, Morita T, Iwanaga S . Purification and properties of intracellular clotting factor, factor B, from horseshoe crab (Tachypleus tridentatus) hemocytes . Journal of Biochemistry . 99 . 3 . 847–57 . March 1986 . 10.1093/oxfordjournals.jbchem.a135545 . 3519594 .
  2. Iwanaga . S . Biochemical principle of Limulus test for detecting bacterial endotoxins. . Proceedings of the Japan Academy. Series B, Physical and Biological Sciences . May 2007 . 83 . 4 . 110–9 . 10.2183/pjab.83.110 . 24019589 . 3756735. 2007PJAB...83..110I .