| Season: | 2010–11 |
| Winners: | FC Barcelona Borges |
| Relegated: | Toledo & Alcobendas |
| Continentalcup1: | EHF Champions League |
| Continentalcup1 Qualifiers: | Barcelona Borges, Renovalia Ciudad Real & Reale Ademar |
| Continentalcup2: | EHF Cup |
| Continentalcup2 Qualifiers: | Fraikin Granollers, Cuatro Rayas Valladolid & CAI BM Aragón |
| League Topscorer: | Rafael Baena (Antequera) – 179 goals |
| Biggest Home Win: | Cuatro Rayas Toledo 44–21 Toledo |
| Biggest Away Win: | Alcobendas 26–40 Naturhouse La Rioja |
| Highest Scoring: | Reale Ademar 34–41 Ciudad Real |
| Matches: | 240 |
| Total Goals: | 13620 |
| Nextseason: | 2011–12 |
Liga ASOBAL 2010–11 season was the 21st since its establishment. Ciudad Real were the defending champions, having won their 5th La Liga title in the previous season. The campaign began on Saturday, 11 September 2010. The league was originally scheduled to end on 21 May 2011. A total of 16 teams contested the league, 14 of which had already been contested in the 2009–10 season, and two of which were promoted from the División de Plata.
Barcelona Borges won their tenth ASOBAL title.
Teams promoted from 2009–10 División de Honor B de Balonmano
Teams relegated to 2010–11 División de Honor B de Balonmano
| Team | Venue | Capacity | |
|---|---|---|---|
| Alcobendas | Severo Ochoa | 3,000 | |
| Antequera | Fernando Argüelles | 2,575 | |
| Arrate | Polideportivo Ipurua | 3,500 | |
| CAI BM Aragón | Príncipe Felipe | 12,000 | |
| Barcelona Borges | Palau Blaugrana | 8,250 | |
| Renovalia Ciudad Real | Quijote Arena | 5,107 | |
| Cuenca 2016 | El Sargal | 1,900 | |
| Fraikin Granollers | Palau D'Esports | 6,500 | |
| Alser Puerto Sagunto | Pabellón Municipal | 1,500 | |
| Toledo | Javier Lozano Cid | 2,500 | |
| Naturhouse La Rioja | Palacio de los Deportes | 3,851 | |
| Quabit Guadalajara | Multiusos de Guadalajara | 5,894 | |
| Cuatro Rayas Valladolid | Huerta del Rey | 3,500 | |
| AMAYA Sport S.A. | Pabellón Universitario | 3,000 | |
| Reale Ademar León | Palacio Municipal | 6,000 | |
| Torrevieja | Palacio de los Deportes | 4,500 |
| Team | P | W | D | L | G+ | G− | Dif | Pts | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Barcelona Borges | 30 | 29 | 0 | 1 | 1003 | 747 | 256 | 58 | |
| 2 | Renovalia Ciudad Real | 30 | 27 | 0 | 3 | 986 | 777 | 209 | 54 | |
| 3 | Reale Ademar | 30 | 20 | 4 | 6 | 937 | 853 | 84 | 43 | |
| 4 | Fraikin Granollers | 30 | 20 | 1 | 9 | 911 | 796 | 115 | 43 | |
| 5 | Cuatro Rayas Valladolid | 30 | 20 | 1 | 9 | 878 | 795 | 83 | 41 | |
| 6 | CAI BM Aragón | 30 | 18 | 4 | 8 | 902 | 853 | 49 | 40 | |
| 7 | AMAYA Sport S.A. | 30 | 15 | 2 | 13 | 840 | 816 | 24 | 32 | |
| 8 | Cuenca 2016 | 30 | 13 | 2 | 15 | 814 | 836 | –22 | 28 | |
| 9 | Naturhouse La Rioja | 30 | 13 | 0 | 17 | 820 | 840 | –20 | 26 | |
| 10 | Antequera | 30 | 12 | 2 | 16 | 796 | 839 | –43 | 24 | |
| 11 | Torrevieja | 30 | 10 | 2 | 18 | 734 | 823 | –89 | 22 | |
| 12 | Alser Puerto Sagunto | 30 | 8 | 4 | 18 | 811 | 883 | –72 | 21 | |
| 13 | Quabit Guadalajara | 30 | 6 | 6 | 18 | 832 | 919 | –87 | 18 | |
| 14 | Arrate | 30 | 5 | 4 | 21 | 740 | 877 | –137 | 14 | |
| 15 | Toledo | 30 | 4 | 3 | 23 | 799 | 945 | –146 | 11 | |
| 16 | Alcobendas | 30 | 1 | 3 | 26 | 730 | 930 | –200 | 5 |
| EHF Champions League | ||
| EHF Cup | ||
| EHF Cup Winners' Cup | ||
| Relegated to División de Honor B |
| Player | Goals | Team | |
|---|---|---|---|
 Rafael Baena | 179 | Antequera | |
 Martin Straňovský | 161 | Reale Ademar León | |
 Jorge Paván | 161 | Cuenca 2016 | |
 Nikola Prce | 157 | Alser Puerto Sagunto | |
| Rafael da Costa | 154 | Cuenca 2016 | |
| Novica Rudović | 153 | Quabit Guadalajara | |
| Juanín García | 152 | Barcelona Borges | |
 Håvard Tvedten | 148 | Cuatro Rayas Valladolid | |
| David Cuartero | 148 | Torrevieja | |
| Antonio García | 146 | Fraikin Granollers |