Liane Jakob-Rost (born 1928 in Berlin) is a German Assyriologist.
Liane Jakob-Rost studied Ancient Near Eastern languages at the University of Berlin. From 1949 she worked at the Vorderasiatisches Museum Berlin in Berlin, as an academic employee after she received her doctorate in 1952. From 1958, she was curator of the collection and in this position she was responsible for the re-incorporation of the looted art returned by the Soviet Union at that time into the collection. In 1978 she succeeded as director of the museum. She retired from this position in 1990 and was succeeded by .
Jakob-Rost's research focus was the editing and publication of cuneiform sources in the museum's collection. She gave presentations in Germany and abroad, and also participated in several overseas exhibitions. She was involved in excavations in Bulgaria and Iraq.