Lexitropsin Explained

Lexitropsins are members of a family of semi-synthetic DNA-binding ligands.^[1] They are structural analogs of the natural antibiotics netropsin and distamycin. Antibiotics of this group can bind in the minor groove of DNA with different sequence-selectivity.^{[2] [3]} Lexitropsins form a complexes with DNA with stoichiometry 1:1 and 2:1. Based on the 2:1 complexes were obtained ligands with high sequence-selectivity.^[4]

See also

• Hoechst 33258
• Pentamidine
• DNA binding ligand
• Single-strand binding protein
• Comparison of nucleic acid simulation software

Notes and References

1. Sondhi S.M. . Praveen Reddy B.S. . Lown J.W. . Lexitropsin conjugates: Action on DNA targets . Current Medicinal Chemistry . 4 . 313–358 . 1997. 5 . 10.2174/0929867304666220313122616 . 247445486 .
2. 10.1021/bi00051a013 . Goodsell . D.S. . Ng . H.L. . Kopka . M.L. . Lown . J.W. . Dickerson . R.E. . Structure of a dicationic monoimidazole lexitropsin bound to DNA . Biochemistry . 34 . 16654–61 . 1995 . 8527438 . 51.
3. Goodsell . D.S. . Sequence recognition of DNA by lexitropsins . Curr Med Chem . 8 . 509–16 . 2001 . 11281838 . 5 . 10.2174/0929867003373319.
4. Kopka . M.L. . Goodsell . D.S. . Han . G. Won . Chiu . Th.K. . Lown . J.W. . Dickerson . R.E. . Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G . Structure . 5 . 1033–1046 . 1997 . 8 . 10.1016/s0969-2126(97)00255-4. 9309219 . free .