Levonorgestrel acetate explained

Levonorgestrel acetate (LNG-A), or levonorgestrel 17β-acetate, also known as 3-ketonorgestimate, is a progestin which was never marketed.^{[1] [2] [3] [4]} It is a progestogen ester and is the C17β acetate ester and a prodrug of levonorgestrel. Norgestimate is the C3 oxime of LNG-A.^[5] The drug is a minor active metabolite of norgestimate, which is a prodrug of norelgestromin and to a lesser extent of levonorgestrel and LNG-A. LNG-A has high affinity for the progesterone receptor, about 135% of that of promegestone (relative to 150% for levonorgestrel). Along with levonorgestrel butanoate, LNG-A was investigated as a hormonal contraceptive by the Population Council.^[6]

See also

• List of progestogen esters

Notes and References

1. Naderi S, Fotherby K . Long-acting contraceptive agents: in vitro hydrolysis of esters of norethisterone and levonorgestrel . Steroids . 41 . 3 . 397–417 . 1983 . 6419410 . 10.1016/0039-128x(83)90110-1. 28094296 .
2. Kuhl H . Pharmacology of estrogens and progestogens: influence of different routes of administration . Climacteric . 8 . 3–63 . 2005 . Suppl 1 . 16112947 . 10.1080/13697130500148875 . 24616324 .
3. Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH . Classification and pharmacology of progestins . Maturitas . 61 . 1–2 . 171–80 . 2008 . 19434889 . 10.1016/j.maturitas.2008.11.013.
4. Alvarez-Sanchez F, Brache V, Jackanicz T, Faundes A . Evaluation of four different contraceptive vaginal rings: steroid serum levels, luteal activity, bleeding control and lipid profiles . Contraception . 46 . 4 . 387–98 . 1992 . 1486777 . 10.1016/0010-7824(92)90101-x.
5. Book: Sven O. Skouby. Clinical Perspectives on a New Gestodene Oral Contraceptive Containing 20μg of Ethinylestradiol. 15 July 1997. CRC Press. 978-1-85070-786-8. 11–.
6. Book: Population Reports: Injectables and implants. 1987. Department of Medical and Public Affairs, George Washington University.. The Population Council also plans to test vaginal rings with two other progestins, ST-1435 and levonorgestrel acetate, alone and combined with ethinyl estradiol (168)..