Lev T. Perelman Explained

Lev T. Perelman
Field:Biological physics, Bioengineering
Work Institution:Harvard University Harvard Medical School Beth Israel Deaconess Medical Center

Lev T. Perelman is an American biological physicist and bioengineer at Harvard. He holds the Mary Tolan and Edward Grzelakowski Endowed Chair, is a professor of medicine at Harvard Medical School, and is the Director of the Center for Advanced Biomedical Imaging and Photonics at Beth Israel Deaconess Medical Center.[1] He is known for his work on biomedical light scattering spectroscopy and application of optics and spectroscopy to life sciences and developmental and cell biology.[2] [3]

Background and education

Perelman is the son of theoretical physicist Theodore L. Perelman, who solved the Conjugate convective heat transfer problem and made contributions in the development of a two-temperature model that describes electron and phonon temperature distributions in metals heated by ultrashort-pulsed lasers.[4]

Perelman completed his undergraduate degree in theoretical physics from Belarus University and doctoral degree in physics from Institute of Physics in Minsk in 1989. He joined MIT in 1992 as a postdoctoral fellow in biological physics.[5]

Career

Perelman was appointed a principal scientist at MIT in 1995. He joined Harvard faculty in 2000 where he is currently a professor.

Perelman was a member of the United States Department of Health and Human Services Joint Working Group charged with setting up funding priorities in oncologic imaging in the U.S.[6]

Research

Perelman with Vadim Backman, an HST graduate student, introduced biomedical light scattering spectroscopy (LSS) in 1998.[7] This approach was later applied for detection of precancer in esophagus,[8] [9] colon,[10] urinary bladder and oral cavity,[11] cervix,[12] [13] pancreatic cysts,[14] [15] and bile duct.[16] This technique was later extended to subcellular scales with development of confocal light absorption and scattering spectroscopic microscopy[17] [18] for label-free subcellular functional imaging, sensing chromatin packing in live cells,[19] and demonstrating that exosomes promote tumorigenesis.[20]

Perelman's other contributions include demonstration of the world's first single-molecule detection with Surface-enhanced Raman Spectroscopy (SERS),[21] and explanation of the critical role of stress confinement in short pulse laser ablation and laser surgery.[22] He also developed with John Marshall the first non-hydrostatic model of the ocean known as the MIT General Circulation Model.[23] [24]

References

  1. Web site: Lev Perelman Harvard Profile . https://web.archive.org/web/20221207211238if_/https://scholar.harvard.edu/perelman . dead . 2022-12-07 . Harvard University.
  2. Web site: Light-scattering tool peers into pancreas to find cancer . 2023-04-03 . NSF - National Science Foundation . en.
  3. News: WINTERS . CATHERINE . 16 June 2017 . The Latest Cancer Research News to Cheer About . . April 2, 2023.
  4. Anisimov . SI . Kapeliovich . BL . Perelman . TL . February 1974 . Electron emission from metal surfaces exposed to ultrashort laser pulses . Soviet Physics JETP . 39 . 2.
  5. Ilev . Ilko K. . Boppart . Stephen A. . Andersson-Engels . Stefan . Kim . Beop-Min . Perelman . Lev . Tuchin . Valery . March 2014 . Introduction to the issue on biophotonics . IEEE Journal of Selected Topics in Quantum Electronics . 20 . 2 . 4–7 . 10.1109/JSTQE.2014.2313622 . 2014IJSTQ..20....4I . 1558-4542.
  6. Qiu . Le . Zhang . Lei . Turzhitsky . Vladimir . Khan . Umar . Zakharov . Yuri . Kantekure . Kanchan . Vitkin . Edward . Itzkan . Irving . Pleskow . Douglas K. . Sawhney . Mandeep . Berzin . Tyler M. . Goldsmith . Jeffrey D. . Perelman . Lev T. . 2019 . Multispectral Endoscopy with Light Gating for Early Cancer Detection . IEEE Journal of Selected Topics in Quantum Electronics . 25 . 1 . 7201309 . 10.1109/JSTQE.2018.2854608 . 1077-260X . 6594557 . 31244520. 2019IJSTQ..2554608Q .
  7. Perelman . L. T. . Backman . V. . Wallace . M. . Zonios . G. . Manoharan . R. . Nusrat . A. . Shields . S. . Seiler . M. . Lima . C. . Hamano . T. . Itzkan . I. . Van Dam . J. . Crawford . J. M. . Feld . M. S. . 1998-01-19 . Observation of Periodic Fine Structure in Reflectance from Biological Tissue: A New Technique for Measuring Nuclear Size Distribution . Physical Review Letters . 80 . 3 . 627–630 . 10.1103/PhysRevLett.80.627. 1998PhRvL..80..627P .
  8. Wallace . Michael B. . Perelman . Lev T. . Backman . Vadim . Crawford . James M. . Fitzmaurice . Marianne . Seiler . Maurice . Badizadegan . Kamran . Shields . Steven J. . Itzkan . Irving . Dasari . Ramachandra R. . Van Dam . Jacques . Feld . Michael S. . 2000-09-01 . Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattering spectroscopy . Gastroenterology . en . 119 . 3 . 677–682 . 10.1053/gast.2000.16511 . 10982761 . 0016-5085.
  9. Qiu . Le . Pleskow . Douglas K. . Chuttani . Ram . Vitkin . Edward . Leyden . Jan . Ozden . Nuri . Itani . Sara . Guo . Lianyu . Sacks . Alana . Goldsmith . Jeffrey D. . Modell . Mark D. . Hanlon . Eugene B. . Itzkan . Irving . Perelman . Lev T. . May 2010 . Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus . Nature Medicine . en . 16 . 5 . 603–606 . 10.1038/nm.2138 . 20383155 . 3052700 . 1546-170X.
  10. Gurjar . Rajan S. . Backman . Vadim . Perelman . Lev T. . Georgakoudi . Irene . Badizadegan . Kamran . Itzkan . Irving . Dasari . Ramachandra R. . Feld . Michael S. . November 2001 . Imaging human epithelial properties with polarized light-scattering spectroscopy . Nature Medicine . en . 7 . 11 . 1245–1248 . 10.1038/nm1101-1245 . 11689891 . 10756302 . 1546-170X.
  11. Backman . V. . Wallace . M. B. . Perelman . L. T. . Arendt . J. T. . Gurjar . R. . Müller . M. G. . Zhang . Q. . Zonios . G. . Kline . E. . McGillican . T. . Shapshay . S. . Valdez . T. . Badizadegan . K. . Crawford . J. M. . Fitzmaurice . M. . July 2000 . Detection of preinvasive cancer cells . Nature . en . 406 . 6791 . 35–36 . 10.1038/35017638 . 10894529 . 4383575 . 1476-4687.
  12. Georgakoudi . Irene . Sheets . Ellen E. . Müller . Markus G. . Backman . Vadim . Crum . Christopher P. . Badizadegan . Kamran . Dasari . Ramachandra R. . Feld . Michael S. . 2002-03-01 . Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo . American Journal of Obstetrics and Gynecology . en . 186 . 3 . 374–382 . 10.1067/mob.2002.121075 . 11904594 . 0002-9378.
  13. Sokolov . Konstantin . Drezek . Rebekah . Gossage . Kirk . Richards-Kortum . Rebecca . Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology . 2023-04-03 . Optics Express . 1999 . 5 . 13 . 302–317 . Optica Publishing Group . 10.1364/oe.5.000302. 19401735 . 1999OExpr...5..302S . free .
  14. Zhang . Lei . Pleskow . Douglas K. . Turzhitsky . Vladimir . Yee . Eric U. . Berzin . Tyler M. . Sawhney . Mandeep . Shinagare . Shweta . Vitkin . Edward . Zakharov . Yuri . Khan . Umar . Wang . Fen . Goldsmith . Jeffrey D. . Goldberg . Saveli . Chuttani . Ram . Itzkan . Irving . 2017-03-13 . Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy . Nature Biomedical Engineering . en . 1 . 4 . 1–7 . 10.1038/s41551-017-0040 . 29057146 . 5646377 . 2157-846X.
  15. Pogue . Brian W. . Wang . Kenneth K. . 2017-04-12 . Cancer diagnostics: Light scattering by pancreatic cysts . Nature Biomedical Engineering . en . 1 . 4 . 1–2 . 10.1038/s41551-017-0060 . 90919028 . 2157-846X.
  16. Pleskow . Douglas K. . Sawhney . Mandeep S. . Upputuri . Paul K. . Berzin . Tyler M. . Coughlan . Mark F. . Khan . Umar . Glyavina . Maria . Zhang . Xuejun . Chen . Liming . Sheil . Conor J. . Cohen . Jonah M. . Vitkin . Edward . Zakharov . Yuri N. . Itzkan . Irving . Zhang . Lei . 2023-01-07 . In vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy . Nature Communications . en . 14 . 1 . 109 . 10.1038/s41467-022-35780-7 . 36611024 . 9825389 . 2023NatCo..14..109P . 2041-1723.
  17. Itzkan . Irving . Qiu . Le . Fang . Hui . Zaman . Munir M. . Vitkin . Edward . Ghiran . Ionita C. . Salahuddin . Saira . Modell . Mark . Andersson . Charlotte . Kimerer . Lauren M. . Cipolloni . Patsy B. . Lim . Kee-Hak . Freedman . Steven D. . Bigio . Irving . Sachs . Benjamin P. . 2007-10-30 . Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels . Proceedings of the National Academy of Sciences . en . 104 . 44 . 17255–17260 . 10.1073/pnas.0708669104 . 0027-8424 . 2077242 . 17956980 . 2007PNAS..10417255I . free .
  18. Cassiday . Laura . 2008-01-01 . Bio Sphere: A first CLASS microscope . Analytical Chemistry . en . 80 . 1 . 29 . 10.1021/ac085998b . 0003-2700. free .
  19. Pettinato . Giuseppe . Coughlan . Mark F. . Zhang . Xuejun . Chen . Liming . Khan . Umar . Glyavina . Maria . Sheil . Conor J. . Upputuri . Paul K. . Zakharov . Yuri N. . Vitkin . Edward . D’Assoro . Antonino B. . Fisher . Robert A. . Itzkan . Irving . Zhang . Lei . Qiu . Le . 2021-08-20 . Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids . Science Advances . en . 7 . 34 . eabj2800 . 10.1126/sciadv.abj2800 . 2375-2548 . 8373132 . 34407934. 2021SciA....7.2800P .
  20. Melo . Sonia A. . Sugimoto . Hikaru . O’Connell . Joyce T. . Kato . Noritoshi . Villanueva . Alberto . Vidal . August . Qiu . Le . Vitkin . Edward . Perelman . Lev T. . Melo . Carlos A. . Lucci . Anthony . Ivan . Cristina . Calin . George A. . Kalluri . Raghu . 2014-11-10 . Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis . Cancer Cell . en . 26 . 5 . 707–721 . 10.1016/j.ccell.2014.09.005 . 25446899 . 4254633 . 1535-6108.
  21. Kneipp . Katrin . Katrin Kneipp . Wang . Yang . Kneipp . Harald . Perelman . Lev T. . Itzkan . Irving . Dasari . Ramachandra R. . Feld . Michael S. . 1997-03-03 . Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS) . Physical Review Letters . 78 . 9 . 1667–1670 . 10.1103/PhysRevLett.78.1667. 1997PhRvL..78.1667K .
  22. Itzkan . I . Albagli . D . Dark . M L . Perelman . L T . von Rosenberg . C . Feld . M S . 1995-03-14 . The thermoelastic basis of short pulsed laser ablation of biological tissue. . Proceedings of the National Academy of Sciences . en . 92 . 6 . 1960–1964 . 10.1073/pnas.92.6.1960 . 0027-8424 . 42402 . 7892208 . 1995PNAS...92.1960I . free .
  23. Marshall . John . Adcroft . Alistair . Hill . Chris . Perelman . Lev . Heisey . Curt . 1997-03-15 . A finite-volume, incompressible Navier Stokes model for studies of the ocean on parallel computers . Journal of Geophysical Research: Oceans . en . 102 . C3 . 5753–5766 . 10.1029/96JC02775. 1997JGR...102.5753M .
  24. Marshall . John . Hill . Chris . Perelman . Lev . Adcroft . Alistair . 1997-03-15 . Hydrostatic, quasi-hydrostatic, and nonhydrostatic ocean modeling . Journal of Geophysical Research: Oceans . en . 102 . C3 . 5733–5752 . 10.1029/96JC02776. 1997JGR...102.5733M . free .

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