Lesinurad/allopurinol explained

Type:combo
Component1:Lesinurad
Class1:urate transporter inhibitor
Component2:Allopurinol
Class2:xanthine oxidase inhibitor
Tradename:Duzallo
Pregnancy Us:N
Legal Us:Rx-only
Legal Eu:Rx-only
Routes Of Administration:By mouth
Atc Prefix:M04
Atc Suffix:AA51
Cas Number:1372858-63-3
Kegg:D11175

Lesinurad/allopurinol (trade name Duzallo) is a fixed-dose combination drug for the treatment of gout.[1] It contains 200 mg of lesinurad and 300 mg of allopurinol. In August 2017, the US Food and Drug Administration approved it for the treatment of hyperuricemia associated with gout in patients for whom target serum uric acid levels have not been achieved with allopurinol alone.[2] It was approved for medical use in the European Union in August 2018.[3] In February 2019, it was discontinued by its manufacturer for business reasons and is no longer available.[4] [5]

Notes and References

  1. Book: Skidmore-Roth L . Mosby's 2020 Nursing Drug Reference . 2020 . Elsevier Health Sciences . St. Louis, Missouri . 978-0-323-67465-2 . e1 . 33rd .
  2. Web site: FDA Clears First Fixed-Dose Combination Treatment for Gout . August 21, 2017 . Medscape.
  3. Web site: Duzallo EPAR . European Medicines Agency (EMA) . 17 September 2018 . 19 August 2020.
  4. Web site: Duzallo and Zurampic . Ironwood Pharmaceuticals . 31 July 2020 . 10 August 2020 . https://web.archive.org/web/20200810085743/https://www.duzallohcp.com/ . dead .
  5. Web site: Withdrawal Zurampic and Duzallo . Grunenthal . 13 January 2019 . 19 August 2020.