| Les Hughson | |
| Fullname: | Leslie William Mitchell Hughson |
| Birth Date: | 12 September 1907 |
| Birth Place: | Richmond, Victoria |
| Death Place: | Heidelberg West, Victoria |
| Height: | 188 cm |
| Weight: | 90 kg |
| Position: | Ruckman |
| Statsend: | 1937 |
| Years1: | 1927 |
| Club1: | Collingwood |
| Games Goals1: | 1 (1) |
| Years2: | 1928 |
| Club2: | Hawthorn |
| Games Goals2: | 4 (3) |
| Years3: | 1933–34 |
| Club3: | Carlton |
| Games Goals3: | 12 (7) |
| Years4: | 1934–36 |
| Club4: | St Kilda |
| Games Goals4: | 41 (45) |
| Years5: | 1937 |
| Club5: | Fitzroy |
| Games Goals5: | 15 (12) |
| Games Goalstotal: | 73 (68) |
Leslie William Mitchell Hughson (12 September 1907 – 22 October 1985) was an Australian rules footballer who played for Collingwood, Hawthorn, Carlton, St Kilda and Fitzroy in the Victorian Football League (VFL).
Hughson is one of only four VFL/AFL footballers to have appeared for five separate clubs. His first port of call was Collingwood but he only played one game for the Magpies before switching allegiances to Hawthorn in 1928.
After his season at Hawthorn, the ruckman left the league for the Victorian Football Association and spent the next four years at Preston. He then had a stint at Carlton in 1934 before crossing to St Kilda mid season. It was at St Kilda that he played his only full season and he kicked 27 goals for them in 1935.
His fifth and final club was Fitzroy, a club that his brothers Fred and Mick also played for during their careers.