Lergotrile Explained

Lergotrile is an ergoline derivative which acts as a dopamine receptor agonist. It was developed for the treatment of Parkinson's disease, but failed in clinical trials due to liver toxicity.[1] [2]

Notes and References

  1. Lieberman AN, Gopinathan G, Estey E, Kupersmith M, Goodgold A, Goldstein M . Lergotrile in Parkinson disease: further studies . Neurology . 29 . 2 . 267–72 . February 1979 . 34808 . 10.1212/wnl.29.2.267 .
  2. Cunningham KA, Callahan PM, Appel JB . Discriminative stimulus properties of lergotrile . The Journal of Pharmacology and Experimental Therapeutics . 230 . 1 . 47–52 . July 1984 . 6146709 .

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