Leonard Herzenberg Explained

Birth Name:Leonard Arthur Herzenberg
Birth Date:1931 11, mf=y
Birth Place:New York City, US
Death Place:Stanford, California, US
Fields:Immunology, genetics
Workplaces:Stanford University
Pasteur Institute
Alma Mater:Brooklyn College
California Institute of Technology
Thesis Title:Studies on a Cytochrome Destroying System in Neurospora
Thesis Year:1956
Thesis Url:https://web.archive.org/web/20050319023509/http://herzenberg.stanford.edu/Herz/lenherz.htm
Doctoral Advisor:Herschel K. Mitchell[1]
Known For:Flow cytometry (FACS)[2]
Awards:Kyoto Prize (2006)
Spouse:Leonore Herzenberg
Children:4, including Jana

Leonard Arthur "Len" Herzenberg (November 5, 1931 – October 27, 2013) was an immunologist, geneticist and professor at Stanford University. His contributions to the development of cell biology made it possible to sort viable cells by their specific properties.[3] [4] [5] [6] [7]

Education

Herzenberg was born in New York City, on November 5, 1931. He received his bachelor's degree in 1952 from Brooklyn College in biology and chemistry. In 1955, he received his Ph.D. from California Institute of Technology in biochemistry with a specialization in immunology for studies on cytochrome in Neurospora.[1]

Career

After school he was a postdoctoral fellow at the American Cancer Society, working in France at the Pasteur Institute. He returned to the United States in 1957 and worked for the National Institutes of Health as an officer in the Public Health Service department. He started working at Stanford in 1959. He eventually earned the title Professor of Genetics.[6]

In 1970 Herzenberg developed the fluorescence-activated cell sorter[2] [6] which revolutionized immunology and cancer biology, and is the basis for purification of adult stem cells.

During a sabbatical in the laboratory of Cesar Milstein between 1976 and 1977, Herzenberg coined the term hybridoma for hybrid cells that result from the fusion of B cells and myeloma cells.[8]

Personal life

Herzenberg and his wife, Leonore Herzenberg,[3] ran the Herzenberg Laboratory at Stanford together[9] until his death. Their daughter, Jana Herzen, is a singer-songwriter and the founder of Motéma Music. He died on October 27, 2013, aged 81.[5]

Awards and honours

Herzenberg received a range of honours and awards during his life including:

External links

Notes and References

  1. PhD . Leonard. Herzenberg . Studies on a cytochrome destroying system in Neurospora . California Institute of Technology . 1956 . Leonard Herzenberg.
  2. Herzenberg . L. A. . Parks . D. . Sahaf . B. . Perez . O. . Roederer . M. . Herzenberg . L. A. . The history and future of the fluorescence activated cell sorter and flow cytometry: A view from Stanford . Clinical Chemistry . 48 . 10 . 1819–1827 . 2002 . 10.1093/clinchem/48.10.1819 . 12324512. free .
  3. Herzenberg . Leonard A. . Herzenberg . Leonore A. . Roederer . M. . A Conversation with Leonard and Leonore Herzenberg . 10.1146/annurev-physiol-021113-170355 . Annual Review of Physiology . 76 . 130819115335001 . 2013 . 23957332 . free .
  4. Roederer . M.. Leonard Herzenberg (1931–2013) Immunologist who pioneered cell-sorting technology. 10.1038/504034a . Nature . 504 . 7478 . 34 . 2013 . 24305144. free .
  5. Web site: Len Herzenberg - 1931-2013 . Roederer . Mario . October 28, 2013 . Purdue University Cytometry Laboratories . October 29, 2013.
  6. Web site: The History of the Cell Sorter Interviews . Record Unit 9554 . . 9 March 2012.
  7. Kalte, Pam M.; Nemeh, Katherine H.; and Schusterbauer, Noah (2005) "Herzenberg, Leonard Arthur (1931-)" American Men & Women of Science: A biographical directory of today's leaders in physical, biological and related sciences (22nd ed.)Thomson Gale, Detroit;
  8. Milstein . César . 1999-10-11 . The hybridoma revolution: an offshoot of basic research . BioEssays . en . 21 . 11 . 966–973 . 10.1002/(SICI)1521-1878(199911)21:11<966::AID-BIES9>3.0.CO;2-Z. 10517870 .
  9. News: McCarthy. Pumtiwitt. The road well traveled together: A joint "Reflections" by Leonore and Leonard Herzenberg. 26 August 2015. ASBMB Today. 2012.
  10. Web site: Past Recipients . The American Association of Immunologists . 19 September 2018.