Lelis syndrome explained

Synonyms:	Ectodermal dysplasia-acanthosis nigricans syndrome
Lelis syndrome
Field:	Medical genetics

Lelis syndrome is a genetic disorder, a rare condition with dermatological and dental findings^[1] characterized by the association of ectodermal dysplasia (hypotrichosis and hypohidrosis) with acanthosis nigricans. Other clinical features may include palmoplantar hyperkeratosis, nail dystrophy, intellectual deficit,^[2] disturbances of skin pigmentation (perioral and periorbital hyperpigmentation, vitiligo, and perinevic leukoderma) and hypodontia. Transmission is autosomal recessive.^[3]

See also

• List of cutaneous conditions

Notes and References

1. Samdani AJ . Ectodermal dysplasia with acanthosis nigricans (Lelis' syndrome) . . 14 . 10 . 626–7 . October 2004 . . 15456556 .
2. Lelis J . Autosomal recessive ectodermal dysplasia . Cutis . 49 . 6 . 435–7 . June 1992 . 1628512 .
3. Steiner CE, Cintra ML, Marques-de-Faria AP . Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome) . . 113 . 4 . 381–4 . December 2002 . 12457412 . 10.1002/ajmg.b.10787 .