Lei Stanley Qi Explained

Lei Stanley Qi
Birth Name:	Qi Lei (亓磊)
Birth Place:	Shandong, China
Nationality:	Chinese
Fields:	Genome engineering, Synthetic Biology
Workplaces:	Stanford, Chemical and Systems Biology
Alma Mater:	Tsinghua University (B.A.) UC Berkeley (Ph.D.)
Academic Advisors:	Adam Arkin, Jennifer Doudna
Known For:	CRISPRi, dCas9，CRISPR imaging，CRISPR-GO
Awards:	Sloan Research Fellowship (2017) Pew Scholar (2016) NIH Directors Early Independence Award (2013)
Website:

Lei "Stanley" Qi is an associate professor in the department of bioengineering, and the department of chemical and systems biology at Stanford University. Qi led the development of the first catalytically dead Cas9 lacking endonuclease activity (dCas9), which is the basis for CRISPR interference (CRISPRi). His laboratory subsequently developed CRISPR-Genome Organization (CRISPR-GO).

Qi is a co-inventor of the University of California patent on the CRISPR gene-editing technology.

Early life and education

Qi obtained his B.S. in physics and math from Tsinghua University,^[1] China, Master in physics from UC Berkeley, and PhD in bioengineering from UC Berkeley.^[2] During his PhD work at Berkeley, he studied synthetic biology with Adam Arkin, and was the first to explore engineering the CRISPR for targeted gene editing and gene regulation with Jennifer Doudna.^[3] After PhD, he performed independent research work as a faculty fellow at UCSF.^[4] He joined the Stanford faculty in 2014.^{[5] [6] [7] [8] [9] [10] [11]}

Award

Qi has won awards, including NIH Director's Early Independence Award,^[12] Pew Biomedical Scholar,^[13] and Alfred. P. Sloan Fellowship.^[14]

External links

• Qi Lab in Stanford
• Qi Lab in UCSF

Notes and References

1. Web site: Tsinghua alumni won the 2017 Sloan Research Award . Tsinghua University News . 24 February 2017.
2. Web site: BioE Rising Star Seminar . berkeley bioengineering . 11 April 2018.
3. Cell scientist to watch – Lei Stanley Qi . Cell Science . 2016 . 129 . 3 . 303–9 . 182196 . 2041082 . Greenwood . D. . O'Grady . F. .
4. Web site: Stanley Lab in UCSF .
5. Web site: Stanley Lab in Stanford .
6. 23452860. 2013. Qi. LS*. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 152. 5. 1173–83. Larson. M. H.. Gilbert. L. A.. Doudna. J. A.. Weissman. J. S.. Arkin. A. P.. Lim. W. A.. 10.1016/j.cell.2013.02.022. 3664290.
7. 23849981. 2013. Gilbert. LA. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.. Cell. 154. 2. 442–51. Larson. MH. Morsut . L. Liu . Z. Brar . GA . Torres . SE. Stern-Ginossar . N . Brandman . O. Whitehead . EH . Doudna . JA . Lim . WA . Weissman . JS . Qi . LS. 10.1016/j.cell.2013.06.044. 3770145 .
8. 26670017. 2016. Dominguez. AA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Nat Rev Mol Cell Biol. 17. 1. 5–15. Lim . WA. Qi . LS. 10.1038/nrm.2015.2. 4922510 .
9. 30318144. 6239909. 2018. Wang. H. CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization. Cell. S0092-8674. 18. 31185–1. Xu. X. Nguyen . CM. Liu. Y . Gao. Y . Lin . X . Daley . TP. Kipniss . NH. La Russa . M. Qi . LS*. 10.1016/j.cell.2018.09.013.
10. 24360272. 2014. Chen . B. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. S0092-8674. 18. 31185–1. Gilbert . LA. Cimini . BA. Schnitzbauer . J . Zhang . W . Li . GW . Park . J. Blackburn. EH . Weissman . JS . Qi . LS . Huang . B . 10.1016/j.cell.2013.12.001. 3918502 .
11. 28481362. 2017. Du . D. Genetic interaction mapping in mammalian cells using CRISPR interference.. Nat Methods. 14. 6 . 577–580. Roguev . A. Gordon . DE . Chen . M . Chen . SH. Shales . M . Shen . JP. Ideker . T . Mali . P. Qi . LS . Krogan. NJ. 10.1038/nmeth.4286. 5584685 .
12. Web site: NIH Director's Early Independence Award Recipients 2013 Awardees . NIH.
13. Web site: Pew Biomedical Scholars . Pew.
14. Web site: Sloan Foundation Past Fellows . Sloan Foundation Web.