| Le Mesnil-Guillaume | |
| Commune Status: | Commune |
| Arrondissement: | Lisieux |
| Canton: | Lisieux |
| Insee: | 14421 |
| Postal Code: | 14100 |
| Mayor: | Alain Mignot[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | CA Lisieux Normandie |
| Coordinates: | 49.1053°N 0.2886°W |
| Elevation M: | 60 |
| Elevation Min M: | 57 |
| Elevation Max M: | 171 |
| Area Km2: | 3.85 |
Le Mesnil-Guillaume (in French pronounced as /lə mɛnil ɡijom/) is a commune in the Calvados department in the Normandy region in northwestern France.