| Le Guislain | |
| Commune Status: | Commune |
| Arrondissement: | Saint-Lô |
| Canton: | Villedieu-les-Poêles-Rouffigny |
| Insee: | 50225 |
| Postal Code: | 50410 |
| Mayor: | Michel Lhullier[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Villedieu Intercom |
| Coordinates: | 48.9728°N -1.2272°W |
| Elevation Min M: | 100 |
| Elevation Max M: | 141 |
| Area Km2: | 5.39 |
| Demonym: | Guislenais |
Le Guislain (in French pronounced as /lə ɡilɛ̃/) is a commune in the Manche department in north-western France.
In 2019, it had a population of 143.