Laura Niklason Explained
Laura Elizabeth Niklason is a physician, professor and internationally recognized researcher in vascular and lung tissue engineering. She is the Nicholas M. Greene Professor of Anesthesiology and Biomedical Engineering at Yale University[1] and co-founder, chief executive officer and president of Humacyte, a regenerative medicine company developing bioengineered human tissues.[2]
Her work on lab-grown lungs was recognized as one of the top 50 most important inventions of 2010 by Time magazine.[3] [4] Niklason was included on Fortune’s “Digital Health Care Leaders” list in 2017 for her work in regenerative medicine.[5]
Niklason was inducted into the National Academy of Inventors in 2014.[6] In 2015, she was elected to the National Academy of Medicine.[7] In 2020, Niklason was elected a member of the National Academy of Engineering for cardiovascular tissue engineering, lung regeneration, and biomedical imaging.[8] [9] She holds more than 30 issued or pending patents in the United States.
Early life and education
Laura Niklason was born in Evanston, Ill. She earned a B.S. in physics and a B.A. in biophysics from the University of Illinois (Urbana-Champaign campus) in 1983. She holds an M.D. from the University of Michigan and a Ph.D. in biophysics from the University of Chicago. Niklason completed her medical training in anesthesiology and critical care medicine at Massachusetts General Hospital in 1996.[10]
Career
Niklason was a faculty member at Duke University from 1998 to 2005. In 2004, Niklason along with Drs. Shannon Dahl and Juliana Blum, co-founded Humacyte, a company based in Durham, North Carolina, that is pioneering the development and manufacture of off-the-shelf, universally implantable, bioengineered human tissues to improve the lives of patients and transform the practice of medicine.[11] In 2006, Niklason joined the faculty at the Yale School of Medicine, where she currently serves as an adjunct professor of anesthesia and biomedical engineering.[12]
In 2010, Niklason and her colleagues were able to successfully produce an engineered rat lung that could inhale and exhale carbon dioxide.[13] In 2013, Niklason along with Duke researcher Dr. Jeffery Lawson, developed a bioengineered blood vessel, which Lawson grafted into an artery in a Duke patient's arm.[14]
In 2016, Niklason was named as the Nicholas M. Greene Professor of Anesthesiology and Biomedical Engineering at Yale.[15] As part of a research team, Niklason conducted clinical trials into the effectiveness of giving patients experiencing kidney failure bioengineered blood vessels.[16]
In 2020, Niklason was appointed CEO and president of Humacyte.[17] Under Niklason’s leadership, the company went public through a merger with Alpha Healthcare Acquisition Corp in 2021.[18] [19] [20] [21]
Niklason, a renowned world leader in cellular therapies and regenerative medicine, continues to maintain an active scientific laboratory, and speaks globally on her research in vascular and non-vascular tissue engineering.
Philanthropy
The Brady W. Dougan and Laura E. Niklason House at University of Chicago was named for her.[22]
Awards and honors
Niklason is the recipient of multiple awards and honors, including:
- 2021: Named one of FiercePharma's 2021 Fiercest Women in Biotech.[23]
- 2021: Winner of Triangle Business Journal 2021 Life Sciences Award. Award went to Humacyte, Inc., of which Niklason is the founder.[24]
- 2020: National Academy of Engineering Member
- 2017: Named to Fortune's Digital Health Care Leaders list for her work in regenerative medicine.
- 2017: Cotlove Lectureship Award in Laboratory Medicine[25]
- 2017: Inducted into Women in Technology Hall of Fame[26]
- 2016: Named to 2016 Disruptor 50 Companies. Award went to Humacyte, Inc., of which Niklason is the founder.[27]
- 2015: Winner of FierceMedicalDevices 2016 Fierce 15. Award went to Humacyte, Inc., of which Niklason is the founder.[28]
- 2014: National Academy of Inventors Fellow
- 2011: Winner of Popular Mechanics Breakthrough Innovators Award for 2011, for development of "off-the-self" tissue engineered vascular graft to treat patients with vascular disease. Award went to Humacyte, Inc., of which Niklason is the founder.[29]
- 2011: Winner of Frost & Sullivan Growth, Innovation & Leadership Award 2011, for development of engineered vascular graft. Award went to Humacyte, Inc., of which Niklason is founder.
- 2010: 50 best inventions of 2010 (engineered lung) Time
- 2008: College of Fellows, American Institute for Medical and Biological Engineering (AIMBE)[30]
- 2002: Beeson Physician Scholars Award, American Federation for Aging Research
- 2001: One of 21 U.S. News & World Report Innovators for 2001
- 2001: Hunt scholar, Pratt School of Engineering, Duke University
- 2000: Discover magazine award for technological innovation (finalist in the health category)
- 2000: Selected by the National Academy of Engineering for Symposium on Frontiers of Engineering[31]
- 1999: “Eminent Scientist of the Year,” International Research Promotion Council
Publications
Niklason is the co-author of more than 120 publications. A selected list follows:
- Niklason, L., Gao, J., Abbott, W.M., Hirschi, K.K., Houser, S., Marini, R., Langer, R. "Functional Arteries Grown in Vitro," Science, (1999), 5413, 489 – 493.
- Borel, C., McKee, A., Parra, A., Haglund, M., Solan, A., Prabhakar, V., Sheng, H., Warner, D., Niklason, L. "Possible Role for Vascular Cell Proliferation in Cerebral Vasospasm After Subarachnoid Hemorrhage," Stroke, (2003), 34:427-433.
- Poh, M., Boyer, M., Dahl, S., Pedrotty, D., Banik, S., McKee, J., Klinger, R., Counter, C., Niklason, L. "Blood Vessels Engineered From Human Cells," The Lancet, (2005), 366, 9489; 891–892.
- Gong, Z., Niklason, L. "Small-Diameter Human Vessel Wall Engineered From Bone Marrow-Derived Mesenchymal Stem Cells (hMSCs)," The FASEB Journal, (2008), 22:1635-1648.
- Petersen, T.H., Calle, E.A., Zhao, L., Lee, E.J., Gui, L., Raredon, M.B., Gavrilov, K., Yi, T., Zhuang, Z.W., Breuer, C., Herzog, E., Niklason, L.E. "Tissue-Engineered Lungs for In Vivo Implantation," Science, (2010), 329, 5991; 538–41.
- Dahl, S.L., Kypson, A.P., Lawson, J.H., Blum, J.L., Strader, J.T., Li, Y., Manson, R.J., Tente, W.E., DiBernardo, L., Hensley, M.T., Carter, R., Williams, T.P., Prichard, H.L., Dey, M.S., Begelman, K.G., Niklason L.E. "Readily Available Tissue-Engineered Vascular Grafts," Science Translational Medicine, (2011), 3, 68;68ra9.
- Quint, C., Kondo, Y., Manson, R.J., Lawson, J.H., Dardik, A., Niklason, L.E. Decellularized Tissue-Engineered Blood Vessel as an Arterial Conduit, Proceedings of the National Academy of Sciences of the United States of America, (2011), 108, 22; 9214–9.
- Zhou, J., Niklason, L.E., "Microfluidic Artificial 'Vessels' for Dynamic Mechanical Stimulation of Mesenchymal Stem Cells," Integrative biology: quantitative biosciences from nano to macro, (2012), 4, 12; 1487–97.
- Ghaedi, M., Calle, E.A., Mendez, J.J., Gard, A.L., Balestrini, J., Booth, A., Bove, P.F., Gui, L., White, E.S., Niklason, L.E., "Human iPS Cell-Derived Alveolar Epithelium Repopulates Lung Extracellular Matrix," The Journal of Clinical Investigation, (2013), 123, 11; 4950–62.
- Mendez, J.J., Ghaedi, M., Sivarapatna, A., Dimitrievska, S., Shao, Z., Osuji, C.O., Steinbacher, D.M., Leffell, D.J., Niklason, L.E., "Mesenchymal Stromal Cells form Vascular Tubes When Placed in Fibrin Sealant and Accelerate Wound Healing In Vivo," Biomaterials, (2014).
- Raredon, M.S., Niklason, L.E., "A Call to Craft," Science Translational Medicine, (2014), 6(218):218fs1.
- Gutowski, P., Gage, S.m., Guziewicz, M., Ilzecki, M. Kazimierczak, A., Kirkton, R.D., Niklason, L.E., Pilgrim, A., Prichard, H.L., Przywara, S., Samad, R., Tente, B., Turek, J., Witkiewicz, W., Zapotoczny, N., Zubilewicz, T., Lawson, J.H., "Arterial reconstruction with human bioengineered acellular blood vessels in patients with peripheral arterial disease," Journal of Vascular Surgery, (2020), 72(4):1247-1258.
- Niklason, L.E., Lawson, J.H., "Bioengineered human blood vessels," Science, (2020), 9;370(6513):eaaw8682.
Notes and References
- Web site: Laura Niklason, PhD, MD. 2021-09-21. medicine.yale.edu. en.
- Web site: Company. 2021-09-21. HUMACYTE. en-US.
- Web site: Staff . The Entrepreneurs . PharmaVOICE . August 6, 2018.
- News: Park. Alice. 2010-11-11. The 50 Best Inventions of 2010 - TIME. en-US. Time. 2021-09-21. 0040-781X.
- Web site: 34 Leaders Who Are Changing Health Care. 2021-09-21. Fortune. en.
- Web site: National Academy of Inventors. 2021-09-21. en-US.
- Web site: anonymous. Prof. Laura Niklason Elected To The National Academy of Medicine. 2021-09-21. Yale School of Engineering & Applied Science. en.
- Web site: anonymous. Laura Niklason Elected To The National Academy of Engineering. 2021-09-21. Yale School of Engineering & Applied Science. en.
- News: Dr. Laura Elizabeth Niklason . October 9, 2023 . United States National Academy of Engineering.
- Web site: Organizer/Speaker- Cell Symposia: Engineering Organoids and Organs. 2021-09-21. www.cell-symposia.com.
- Web site: Executive Voice: Her Durham firm pioneers transformation of medicine. 2021-09-21. www.bizjournals.com.
- Web site: Lab Members. 2021-09-21. medicine.yale.edu. en.
- Petersen. Thomas H.. Calle. Elizabeth A.. Zhao. Liping. Lee. Eun Jung. Gui. Liqiong. Raredon. MichaSam B.. Gavrilov. Kseniya. Yi. Tai. Zhuang. Zhen W.. Breuer. Christopher. Herzog. Erica. 2010-07-30. Tissue-Engineered Lungs for in Vivo Implantation. Science. 329. 5991. 538–541. 10.1126/science.1189345. 0036-8075. 3640463. 20576850. 2010Sci...329..538P.
- Web site: Surgeons at Duke University Hospital Implant Bioengineered Vein. 2021-09-21. Duke Health. June 6, 2013 . en.
- Web site: Staff . Dr. Laura Niklason appointed the Nicholas Greene Professor . Yale News . August 6, 2018. 2016-01-06 .
- Web site: Xie. Abigail. Bioengineered blood vessels shown to be effective in patients with kidney failure. The Chronicle. August 6, 2018.
- Web site: 2020-11-20. Humacyte Appoints Founder Laura Niklason MD, PhD as President and Chief Executive Officer. 2021-09-21. www.businesswire.com. en.
- Web site: Humacyte Announces Successful Closing of Business Combination with Alpha Healthcare Acquisition Corp. Humacyte, Inc.. 2021-09-21. humacyte.gcs-web.com. en.
- News: Franklin. Rebecca Spalding, Joshua. 2021-02-17. Human tissue developer Humacyte agrees to SPAC merger to go public. en. Reuters. 2021-09-21.
- Web site: Did You Expect It Would Take This Long To Go Public?. 2021-09-21. www.lifescienceleader.com.
- Web site: Pioneering regenerative med scientist Laura Niklason takes her company public in the latest big SPAC deal. And that gives her a shot at making biotech history. 2021-09-21. Endpoints News. en.
- Web site: Brady W. Dougan and Laura E. Niklason House The University of Chicago Campaign: Inquiry and Impact. campaign.uchicago.edu. en. 2018-08-08.
- Web site: FiercePharma 2021 Fiercest Women: Laura Niklason, Humacyte. 2021-11-15. www.fiercepharma.com. November 15, 2021.
- Web site: 2021 Life Sciences Awards: Humacyte. 2021-09-21. www.bizjournals.com.
- Web site: Previous Award Winners. 2021-09-21. ACLPS. en-US.
- Web site: WITI - Laura Niklason, M.D., Ph.D.. 2021-09-21. www.witi.com.
- Web site: CNBC. 2016-06-07. 2016 CNBC's Disruptor 50. 2021-09-21. www.cnbc.com.
- Web site: Humacyte. 2021-09-21. FierceBiotech. January 23, 2017. en.
- Web site: Ward. Logan. Mechanics. the Editors of Popular. 2011-10-03. 11 Brilliant Innovators: Breakthrough Awards 2011. 2021-09-21. Popular Mechanics. en-US.
- Web site: Laura E. Niklason, MD. Ph.D. COF-0809 - AIMBE. 2021-09-21. en.
- Book: Read "Frontiers of Engineering: Reports on Leading-Edge Engineering From the 2000 NAE Symposium on Frontiers in Engineering" at NAP.edu. 2001. 10.17226/10063. 978-0-309-07319-6. en.